摘要
目的探讨帕罗西汀治疗惊恐发作患者心血管症状的有效性和安全性。方法入选82例住院治疗的以心血管症状为主的惊恐发作患者,随机分为研究组42例和对照组40例。研究组采用帕罗西汀40mg/d,对照组采用舍曲林100mg/d,分别进行为期12周的治疗,每2周记录患者胸痛、濒死感发作次数和汉密尔顿焦虑量表(HAMA)、临床疗效总评量表-病情严重程度(CGI-SI),并进行评定比较。结果研究组痊愈率高于对照组(57.1%vs35.0%),而无效率低于对照组(9.5%vs40.0%)(P<0.05)。研究组治疗第4周起患者胸痛发作次数、HAMA评分及GGI-SI评分与治疗前比较差异有统计学意义(P<0.05),对照组治疗第8周起胸痛发作次数、HAMA评分及GGI-SI评分与治疗前比较差异有统计学意义(P<0.05)。结论帕罗西汀治疗惊恐发作患者心血管症状的疗效优于舍曲林,且较舍曲林起效快。
Objective To approach therapeutical effect of paroxetine to panic attack patients with symptoms of cardiovas- cular system. Methods Totally 82 panic attack admission patients whose cardinal symptoms were in cardiovascular system were enrolled, and were randomly divided intostudy group with 42 patients and control group with 40 patients. Study group took par- oxetine 40 mg/d and control group took sertraline 100 mg/d, the duration were 12 weeks. Attacks of chest pain and feeling of impending death, HAMA, CGI-SI were recorded every 2 weeks. Results Recovery rate in study group was higher than con- trol group （57.1 % vs 35.0 %）, hut ineffeetive rate was contrary （9. 5 % vs 40.0 % ）. The difference was significant （P〈0.05） .Attacks of chest pain, HAMA and CGI-SI in study group compared with pre-therapy had significant difference when took medicine for 4 weeks（P〈0.05）, but control group had significant difference when took medicine for 8 weeks （P〈0.05）. Con- clusion Paroxetine outweighs sertraline to panic attacks with symptoms of cardiovascular system, and produces a marked effect fast when the patients take paroxetine.
出处
《中国实用神经疾病杂志》
2012年第20期18-19,共2页
Chinese Journal of Practical Nervous Diseases
