摘要
目的 与神经元特异性烯醇化酶 (NSE)对照 ,探讨胃泌素释放肽前体片段 31 98(ProGRP31 98)检测对小细胞肺癌 (SCLC)的临床意义。方法 采用ELISA检测 30例SCLC、30例非小细胞肺癌、15例肺良性疾病、15例正常健康者和 10例治疗后SCLC患者血清ProGRP31 98和NSE值。采用ROC曲线确定阈值 ,比较诊断准确性。结果 SCLC组血清ProGRP31 98值显著高于对照组 (P <0 0 0 0 1) ,广泛期高于局限期 (P =0 0 44 ) ,有远处转移者高于无远处转移者 (P <0 0 0 0 1)。SCLCProGRP31 98升高幅度大于NSE。以 40pg/ml和 8μg/L为阈值 ,SCLCProGRP31 98和NSE敏感性分别为 73%和 6 0 % ,ROC曲线下面积分别为 0 96 39± 0 0 18和 0 872 3± 0 0 36 ,差异有显著性 (P =0 0 0 0 1)。局限期SCLC的二者敏感性分别为 6 7%和 47% ,ROC曲线下面积分别为 0 95 6 5± 0 0 2 0和0 830 7± 0 0 42 ,差异有显著性 (P =0 0 0 0 1)。化疗有效者治疗后ProGRP31 98显著下降 (P =0 .0 18)。结论ProGRP31 98是较NSE更为特异。
Objective To determine the clinical significance of serum level of pro gastrin releasing peptide 31 98 (ProGRP31 98) for small cell lung cancer (SCLC) in comparison with neuron specific enolase (NSE).Methods Serum level of ProGRP31 98 was measured by ELISA in 30 patients with SCLC, 30 patients with non small cell lung cancer (NSCLC), 10 patients with SCLC who had received treatment, 15 patients with benign lung diseases and 15 normal subjects. The receiver operating characteristic (ROC) curve was used to set the cut off value and evaluate the diagnostic accuracy.Results The serum level of ProGRP31 98 was significantly increased in patients with SCLC as compared to that of the normal controls as well as that in any other groups of patients. It was higher in SCLC patients with extensive disease than in patients with limited disease. In patients with distant metastases, it was also higher than in those without. Increase in serum ProGRP31 98 and NSE was both seen in SCLC patients, but the former was of much greater magnitude when compared to the normal controls. Given the cut off levels of 40 pg/ml for ProGRP31 98 and 8 μg/L for NSE, their sensitivity of diagnosis in SCLC was 73% and 60%, respectively. The area under ROC curve of ProGRP31 98 was significantly larger than that of NSE. Similar results of diagnostic sensitivity and area under ROC curve were observed in SCLC patients with limited disease. All patients responded to chemotherapy showed marked decrease in ProGRP31 98.Conclusion ProGRP31 98 is a more specific and sensitive marker than NSE for the diagnosis of SCLC.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2000年第3期216-218,共3页
Chinese Journal of Oncology
