摘要
粒子沥滤法作为常用的制备组织工程支架的方法,这种方法对实验设备和实验条件要求较低,孔隙率、孔径可控。但传统的溶液浇铸/粒子沥滤法也存在一些缺点,只适合制备薄层支架,孔-孔连通性不好,聚合物有可能保留致孔剂和/或有毒溶剂。本文总结了近几年科研工作者对这种方法所进行的改进工作,并探讨了改进的效果和不足。
Porogen leaching method is most commonly used for fabricating micro- and macro-porous polymer scaffolds. The advantage of this method is that the process is easy to carry out and easy to control the pore size and porosity by selecting suitable particle size and amount of the added salt particles. However, most of the scaffolds prepared by this method are limited to two-dimensional films with 2-3mm, and the scaffolds usually have a poor interconnectivity between macropores. Moreover, the porogen and solvent can remain in polymer scaffolds. The development situation of modified porogen leaching method is reviewed in this paper, and the effects and deficiencies of the modification are discussed.
出处
《高分子通报》
CAS
CSCD
北大核心
2012年第11期92-96,共5页
Polymer Bulletin
基金
国家自然科学基金项目(项目号51173039)
归国留学人员择优资助项目(项目号2008-86)
关键词
粒子沥滤
多孔支架
组织工程
Porogen lefiching
Porous scaffold
Tissue engineering
