摘要
生物材料,尤其是血液接触材料,满足抗凝血性能是临床应用的首要前提。采用表面改性策略来提高材料表面的抗凝血性能,简单易行。表面改性主要包括表面设计和方法设计两个方面。本文对抗凝血性高分子生物材料的表面设计各类方法进行了综述,其中包括材料表面的微相分离结构、材料的负电荷表面设计、材料的亲(疏)水性表面设计、材料的生物活性化表面设计和材料的内皮细胞化表面设计等等,并重点阐述了两性离子的抗凝血表面设计。
Biomaterials, especially blood-contact materials, to meet antithrombogenic requirement is the first premise for clinical application. Surface modification for blood compatibility improvement is simple and feasible. Surface modification includes two aspects of surface design and method design. In the present paper, several surface design strategies for antithrombogenic polymeric materials including micro-phase separated structure design, surface phase seperation design, negative charge surface design, hydrophilic/hydrophobic surface design, bioactive surface design, endothelialization surface design, and zwitterionic surface design were reviewed. Among them, zwitterionic antithrombogenic surface design was highlighted.
出处
《高分子通报》
CAS
CSCD
北大核心
2012年第11期12-17,共6页
Polymer Bulletin
基金
国家自然科学基金(21274063)
江苏省高校自然科学基金(11KJD430003)
南京师范大学基金(2011103XGQ0055)
江苏高校优势学科建设工程资助项目(PAPD)
关键词
血液相容性
抗凝血材料
分子工程表面设计
两性离子生物材料
Blood compatibility
Antithrombogenic materials
Molecular engineering surface Design
Zwitterionic biomaterials
