摘要
目的探讨角蛋白19片段K19-2G2检测对肺癌的诊断价值,并与肿瘤相关物质(TSGF)进行比较。方法应用化学发光免疫分析方法检测300例肺癌患者,80例肺部良性疾病患者和200例健康体检者的血清K19-2G2浓度。同时采用TSGF试剂盒检测TSGF的含量。比较三组患者K19-2G2和TSGF的变化。结果三组患者K19-2G2和TSGF比较差异有统计学意义(P<0.05)。300例肺癌患者中K19-2G2阳性检出率为95%,TSGF阳性检出率为73.3%,差异有统计学意义(P<0.05)。肺癌患者K19-2G2血清水平与TSGF血清水平呈正相关。结论角蛋白19片段K19-2G2对肺癌的诊断价值及临床应用效果优于TSGF。
Objective To investigate the diagnostic value of cytokeratin 19 fragment K19-2G2 in lung cancer,and compare it to the detection of tumor supplied group of factors（TSGF）.Methods The serum content of K19-2G2 and TSGF in 300 patients with lung carcinoma,80 patients with benign lung diseases and 200 health volunteers（control group）were measured by chemiluminoimmunoassay and TSGF assay kit.Results K19-2G2 and TSGF differences between the three groups were statistically significant（P0.05）.The positive rate of K19-2G2 in 300 patients with lung carcinoma was 95%,the positive rate of TSGF was 73.3%,the difference was statistically significant（P0.05）.The serum K19-2G2 and TSGF in lung carcinoma patients were positively correlated.Conclusion K19-2G2 detectionhas better diagnostic value and clinical application effect than TSGF for lung carcinoma.
出处
《医学综述》
2012年第21期3677-3679,共3页
Medical Recapitulate
关键词
角蛋白19-2G2
肿瘤相关物质
肺癌
血清
化学发光法
Cytokeratin 19-2G2
Tumor supplied group of factors
Lung cancer
Serum
Chemical luminescence method
