摘要
成纤维细胞生长因子19(FGF19)是新近发现的一种代谢调节因子,由胆汁酸分泌进入肠道后刺激肠道分泌和表达。人类的FGF19与小鼠的FGF15同源。FGF19经肠道分泌后可随循环进入肝脏并与肝脏中的FGFR4结合起作用,它具有激素样作用,发挥着重要的代谢调节作用,如调节胆汁酸代谢、调节胆囊的充盈、提高能量代谢降低体质量、改善血糖等。
Fibroblast growth factor 19（FGF19）,a newly found metabolic regulator,is secreted and expressed when stimulated by bile acid secretion into the intestine.Human FGF19 and mouse FGF15 are homologous.Secreted intestinal FGF19 can go into the liver along with the circulation to combine with FGFR4 to function,which is hormone-like,playing an important role in metabolic regulation：such as the regulation of bile acid metabolism and filling of the gallbladder,improving the energy metabolism to reduce body weight,and improving blood glucose and so on.
出处
《医学综述》
2012年第21期3553-3556,共4页
Medical Recapitulate
基金
上海市科委基础研究重点项目(10JC1412400)
