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脓毒症时高迁移率族蛋白B1干预策略的研究进展 被引量：2

Research Progress of Intervention Strategies of High Mobility Group Protein B1 in Sepsis
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摘要 高迁移率族蛋白B1(HMGB1)作为新的潜在"晚期"炎性介质参与脓毒症的发病过程,在揭示HMGB1作用的分子机制、HMGB1表达、释放规律及药物抑制方面已经取得了一定进展,给临床医师提供了对脓毒症和失控炎性反应实施早期干预的可能。同时,检测血清HMGB1水平也可能成为预测和判断脓毒症患者病情的一种新手段。 A certain progress has been made in the molecular mechanism,expression,release regularity and drug suppression of high mobility group protein B1（HMGB1）as a new potential ＂late＂ inflammatory mediators involved in the pathogenesis of sepsis,which makes it possible for early intervention of sepsis and uncontrolled inflammatory response for clinicians.Besides,detection of serum HMGB1 levels may become a new means to determine the condition of patients with sepsis.
作者 王文江 郭春良
机构地区 武警北京市总队医院普通外科
出处 《医学综述》 2012年第21期3544-3547,共4页 Medical Recapitulate
关键词 脓毒症 高迁移率族蛋白B1 炎性介质 抑制 Sepsis High mobility group protein B1 Inflammatory mediators Inhibit
分类号 R644 [医药卫生—外科学] R71 [医药卫生—妇产科学]
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参考文献34

  • 1Goodwin GH, Sanders C, Johns EW. A newgroup of chromatin-as- sociated proteinwith a high content of acidic and basicamino acids [ J]. Eur J Biochem, 1997,38 ( 1 ) : 14-19.
  • 2Sparrow DB, Well RE Jr. Sequence of a cDNA encoding chicken high-mobility-group protei-2 [ J ]. Gene, 1992,114 (2) :289-290.
  • 3Maher JF, Nathans D. Multivalent DNA-bindingproperties of the HMG-I protein [ J ]. Proc Natl Acad Sci U S A, 1996,93 ( 13 ) : 6716-6720.
  • 4Ohndorf UM, Rould MA, He Q, et al. Basisfor recognition of cispla- tin-modified DNA by high-mobility-group proteins [ J ]. Nature, 1999,399 (6737) :708-712.
  • 5Ulloa L, Messmer D. High-mobility group box 1 (HMGB1)protein: friend and foe [ J ]. Cytokine Growth Factor Rev, 2006, 17 ( 3 ) : 189-201.
  • 6Sappington PL, Yang R, Yang H, et al. HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs in- testinal barrier function in mice [ J ]. Gastroenterology, 2002,123 ( 3 ) :790-802.
  • 7Riedemann NC, Guo RF, Ward PA, et al. The enigma of sepsis [J]. J Clin Invest,2003,112(4) :460-467.
  • 8Wang H,Bloom O,Zhang M,et al. HMG-1 as a late mediator of en- dotoxin lethality in mice [ J ]. Science, 1999,285 ( 5425 ) :248-251.
  • 9Abraham E,Arcaroli J,Carmody A,et al. HMG-1 as a mediator of acute lung injury [ J ]. J Immunol,2000,165 (6) :2950-2954.
  • 10Wang H, Vishnubhakat JM, Bloom O, et al. Proinflammatory cyto- kines( tumor necrosis factor and interleukinl )stimulate release of high mobility group protein-1 by pituicytes[ J. Surgery, 1999 126 (2) :389-392.

二级参考文献21

  • 1黎君友,于燕,郝军,晋桦,许惠君.分光光度法测定血和小肠组织二胺氧化酶活性[J].氨基酸和生物资源,1996,18(4):28-30. 被引量：203
  • 2Wang H, Bloom O, Zhang M, et al. HMG -1 as a late mediator of endotoxin lethality in mice. Science, 1999, 285: 248-251.
  • 3Yang H, Wang H, Tracey KJ. HMG -1 rediscovered as a cytokine. Shock, 2001, 15:247-253.
  • 4Ombrellino M, Wang H, Ajemian MS, et al. Increased serum concentrations of high-mobility-group protein 1 in haemorrhagic shock. Lancet, 1999, 354: 1446-1447.
  • 5Liu SF, Adocock IM, Old RW, et al. Lipopolysaccharide treatment in vivo induces widespread tissue expression of inducible nitric oxide synthase mRNA. Biochem Biophys Res Commun, 1993, 196: 1208-1213.
  • 6Koike K, Moore FA, Moore EE, et al. Endotoxin after gut ischemia-reperfusion causes irreversible lung injury. J Surg Res, 1992, 52: 656-662.
  • 7Abraham E, Arcaroli J, Carmody A, et al. Cutting edge: HMG -1 as a mediator of acute lung inflammation. J Immunol, 2000, 165: 2950-2954.
  • 8Fang WH, Yao YM, Shi ZG, et al. The significance of changes in high mobility group-1 protein mRNA expression in rats after thermal injury. Shock, 2002, 17: 329-333.
  • 9方文慧,姚咏明,施志国,于燕,吴叶,陆连荣,盛志勇.杀菌-通透性增加蛋白对烫伤大鼠脂多糖结合蛋白和CD14 mRNA表达的影响[J].中华医学杂志,1999,79(4):289-291. 被引量：7
  • 10方文慧,姚咏明,施志国,于燕,吴叶,郑玉清.烫伤大鼠内毒素的组织分布特点及意义[J].中华整形烧伤外科杂志,1999,15(4):298-300. 被引量：4

共引文献130

同被引文献39

  • 1张立天,姚咏明,陆家齐,鄢小建,于燕.正丁酸钠对脓毒症大鼠高迁移率族蛋白B1表达的拮抗作用[J].解放军医学杂志,2005,30(10):867-869. 被引量：17
  • 2向迅捷.肠内外营养对危重患者脏器功能影响的对比研究[J].中国危重病急救医学,2006,18(10):613-615. 被引量：43
  • 3中华医学会重症医学分会.危重患者营养支持指导意见(2006)[J].中国实用外科杂志,2006,26(10):721-731.
  • 4Dellinger RP,Levy MM,Rhodes A,et al. Surviving sepsis campaign t international guidelines for management of se- vere sepsis and septic shock, 2012 [J]. Intensive Care Med, 2013,39 (2): 165-228.
  • 5Mantell LL, Parrish WR, Ulloa L. HMGB-1 as a thera- peutic target for infectious and inflammatory disorders [J]. Shock,2006,25(1) :4-11.
  • 6Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Confer- ence Committee. American College of Chest Physicians/ Society of Critical Care Medicine. 1992[J]. Chest, 2009, 136(5 Suppl) :e28.
  • 7杨先芬,荚卫东,许戈良,等.添加丙氨酰原谷氨酰胺肠外营养对肝硬化门静脉高压患者术后的应用研究[J].安徽医科大学学报,2009,16(4):638-639.
  • 8Grau T, Bonet A, Minambres E, et al. The effect of L-alanyl-L-glutamine dipeptide supplemented total parenteral nutrition on infectious morbidity and insulin sensitivity in critically ill patients [J]. Crit Care Med, 2011,39 (6) 1263-1268.
  • 9Engel C,Brunkhorst FM,Bone HG,et al.Epidemiology of sepsis in Germany:results from a national prospective multicenter study[J].Intensive Care Med,2007,33(4):606-618.
  • 10Galley HF.Oxidative stress and mitochondrial dysfunction in sepsis[J].Br J Anaesth,2011,107(1):57-64.

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医学综述
2012年 第21期

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