摘要
目的:探讨大剂量甲氨蝶呤治疗原发性中枢神经系统淋巴瘤过程中的毒副作用及其护理方法。方法:采用回顾性研究方法,对我院2008年12月～2011年10月期间收治的30例原发性中枢神经系统淋巴瘤患者行大剂量甲氨蝶呤治疗过程中出现的毒副反应及其护理措施进行分析。结果:25例患者出现不同程度的胃肠道反应,如恶心、呕吐、食欲不振等;另外表现为骨髓抑制15例;肝肾功能损害12例;口腔溃疡8例以及双下肢皮疹伴肛周皮肤溃疡1例。通过积极护理所有患者均顺利度过化疗反应期。结论:熟悉甲氨蝶呤的毒副作用,加强心理护理,及时发现化疗过程中出现的各种不良反应,并采取积极有效的护理措施,从而保证化疗的顺利进行。
Objective：To investigate the high-dose methotrexate in the treatment of primary central nervous system lymphoma of side effects and nursing method.Methods：A retrospective study method to my courtyard the clinical data of 30 cases with primary central nervous system lymphoma treated with high-dose methotrexate therapy appear in the process of adverse reaction and nursing measures for analysis from December 2008 to October 2011.Results：25 cases of patients with different degrees of gastrointestinal reactions such as nausea,vomiting,loss of appetite,etc.In addition to the suppression of bone marrow in 15 cases,12 cases of liver and kidney function damage,oral ulcer in 8 cases and double lower limb skin rash with perianal skin ulcer in 1 cases.Through active nursing care for all patients were successfully through the period of chemotherapy reaction.Conclusion：To be familiar with methotrexate toxicity,strengthen psychological care,timely detection of chemotherapy during the various adverse reactions,and to take positive and effective nursing measures,so as to ensure the smooth progress of chemotherapy.
出处
《护理实践与研究》
2012年第20期93-95,共3页
Nursing Practice and Research
关键词
原发性中枢神经系统淋巴瘤
甲氨蝶呤
毒副作用
护理
Primary central nervous system lymphoma
High-dose methotrexate
Side effect
Nursing
