摘要
目的 了解神经精神狼疮 (NPL E)的临床特征及治疗转归。方法 回顾 1992～ 1998年在本院风湿科诊治的 2 6例神经精神狼疮的临床资料。结果 2 6例 NPL E患者 5 0 %在起病 1年内发病 ,有器质性脑病综合征 11例 ,脑血管意外 2例 ,癫痫 4例 ,狼疮性头痛 2例 ,精神症状或精神病 7例。 19例重症 NPL E中 ,12例给予甲基强的松龙冲击加免疫抑制剂治疗后 10例病情缓解 ,2例死亡 ;7例单用甲基强的松龙冲击治疗者 4例缓解 ,3例死亡 (P>0 .0 5 )。 7例精神症状为主要表现者 6例以强的松 <10 0 mg/ d剂量加抗精神病药物 ,均在 2周至 2个月内病情缓解。结论 对于重症 NPL E应尽早给予糖皮质激素加免疫抑制剂冲击治疗 ,而精神症状者常规剂量激素加抗精神病药物即有明显疗效。
Objective To explore clinical features, treatment and prognosis of neuro psychological lupus erythematosus (NPLE) Methods Clinical data of 26 SLE patients with neuro psychological manifestations who were hospitalized in Department of Rheumatology of our hospital from year 1992 to 1998 were retrospectively summarized Results In clinical features, among 26 NPLE patients 13 cases occurred within one year after SLE onset, 11 cases presented organic encephalopathy syndrome, 2 cases encephalic stroke, 4 cases epilepsy, 2 cases lupoid encephalodynia, 7 cases psychological manifestations or psychosis In treatment, 12 of 19 servere NPLE patients were intravenously given methoprednisolone plus immuno suppressive agent pulse dose, in which 10 cases remitted, 2 cases died; the other 7 cases were intravenously treated with methoprednisolone pulse dose alone, in which 4 cases remitted, 3 cases died, compared with the above, P >0 05, whereas, 6 of 7 cases with psychological manifestations were administrated with oral prednisone, by dose of less than 100 mg/d, plus anti psychosis drugs, and then remitted within 2 weeks over 2 months Conclusion Glucose cortico steroids plus immuno suppressive agent pulse dose treatment is efficient for severe NPLE patients and conventional dose glucose corticosteroids plus anti psychosis drugs treatment is effective for NPLE patients with psychological manifestations
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
2000年第3期212-213,225,共3页
Journal of Nanjing Medical University(Natural Sciences)
基金
江苏省教委自然科学基金!项目 ( 99KJB 3 2 0 0 0 2 )
关键词
系统性红斑狼疮
神经精神症状
免疫抑制剂
systemic lupus erythematosus
neuro psychological manifestations
immunosuppressive agent
