摘要
目的应用磁共振弥散张量成像(DTI)来研究颢叶癫痫(TLE)患者双侧钩束结构的完整性和连续性,探讨颞叶癫痫患者钩束结构损害对执行控制功能的影响。方法对收录2007年1月～2011年07月在我院门诊或住院的TLE患者30例(左侧14例,右侧16例)和15例健康对照组进行全脑DTI扫描,测量其双侧钩束的各项异性分数(FA)值及纤维束的平均长度,对两组数据进行统计学分析。结果 15例正常对照组中左侧钩束FA值较右侧钩束FA值高(P<0.01);左侧TLE患者较正常对照组左侧钩束的FA值低(P<0.01),右侧钩束的FA值与正常组右侧钩束比较差异无统计学意义(P>0.05);右侧TLE中左侧钩束的FA值较正常组左侧钩束FA值低,二者比较差异有统计学意义(P<0.01),右侧钩束FA值降低,与正常组右侧钩束比较差异有统计学意义(P<0.05);左侧和右侧TLE患者同组间两侧钩束FA值比较差异无统计学意义;正常组和两组患者组内的纤维束平均长度比较及两组患者分别与正常组比较差异均无统计学意义。结论正常人的左侧钩束较右侧钩束的FA值高;无论是左侧还是右侧的TLE,钩束FA值左侧优势不存在,并均出现左侧钩束FA值降低,揭示了TLE患者左侧钩束白质微结构的病理改变明显,有助于寻找TLE患者执行控制功能损害的可能的原因。
Objective To study the structural integrity and continuity of the bilateral uncinate fasciculus （UF） in patients with temporal lobe epilepsy （TLE） using magnetic resonance diffusion tensor imaging （DTI） and evaluate the impact of structural damage of the UF on the executive function of the patients. Methods Thirty patients with TLE （14 left, 16 right） and 15 healthy control subjects underwent DTI scanning between January, 2007 and July, 2011, and the left and right UF were analyzed for fractional anisotropy （FA） and fiber mean length. Results In the control subjects, the average FA was significantly higher in the left than in the right UF （P〈0.01）. In patients with left TLE, the average FA of the left UF was significantly lower than that of the control subjects （P〈0.01）, but the FA of the right UF was comparable with that of the control group （P〉0.05）. In patients with right TLE, the average FA of the left and right UF was significantly lower than that of the control group （P〈0.05 and P〈0.01）. In patients with unilateral TLE, the FA of their bilateral UF was similar. No significant difference was found in the mean length of UF fiber between these 3 groups. Conclusions FA is normally higher in the left UF than in the right UF, but inpatients with TLE, the left FA tends to have a lowered UF regardless of which hemisphere is involved, suggesting an early pathologyin the microstructure of the left UF. This finding may help in the Investigation of possible reasons for executive function damage in TLE patients.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2012年第11期1639-1642,共4页
Journal of Southern Medical University
基金
广西自然科学基金(2011GXNSFA18263)
关键词
弥散张量成像
颞叶癫痫
钩束
diffusion tensor imaging
temporal lobe epilepsy
uncinate fasciculus
