摘要
目的探讨肝内胆管细胞癌临床特点与生物学特点之间的联系,为临床治疗提供更多的帮助。方法回顾性分析华中科技大学同济医学院附属同济医院,自1985年4月至2008年12月间97例肝内胆管细胞癌临床及术后病理资料。结果 1.43.98%(42/97)的患者乙肝表面抗原阳性,男性组阳性率(51.61%)明显高于女性组(28.57%),差异有显著性意义(P<0.05)。2.原发肿瘤位于肝左叶的ICC患者发生转移(67.27%(37/55)明显高于位于肝右叶的ICC患者(40.48%(17/42)),差异具有显著性(P<0.05);3.病理提示肿瘤中-低分化而发生转移(66.67%(34/51))较高分化者(43.48%(20/46))高,差异具有显著性(P<0.05)。4.一年内复发率27.85%(22/79),复发组术中输血率(63.64%(14/22))明显高于未复发组(31.58%(18/57))两者之间差异具有显著性(P<0.05)。结论 1.慢性乙肝或血清学HBV阳性患者中,男性发展成肝内胆管细胞癌的几率更大。2.ICC发生转移特点因肿瘤的位置和分化程度不同而存在差异。3.输血是肿瘤术后复发的危险因素之一。
Objective To investigate the link between clinical features and the biological characteristics of intrahepatic cholangiocarcinoma. Method 97 cases of intrahepatic cholangiocarcinoma of clinical and pathological information were retrospectively analyzed in Wuhan Tongji hospital from April 1985 to December 2008. Results 1. 43.98% （42/97） of patients with hepatitis B sur- face antigen positive in which positive rate of males （51.61%）was significantly higher than the female group （28. 57% ）. The differ- ence was statistically significant （P 〈 0. 05 ）. 2. The primary tumor in the left lobe of the ICC with liver metastasis （67.27% （37/ 55 ） ） significantly higher than the primary tumor in the right lobe （40. 48% （17/42））. The difference was statistically significant （P 〈0. 05） ; 3. It was significant （P 〈0. 05） that moderate-poorly differentiated tumor （66. 67% （34/51） ） tend to metastasis than high differentiated tumor （43.48% （20/46））. 4. Within one year recurrence rate was 27.85% （22/79） ,and relapse group with blood transfusion rate （63.64% （ 14/22 ） ） was significantly higher than non-recurrent group （31.58% （ 18/57 ） ）. Univariate analysis showed that blood transfusion is a risk factor for recurrence. Conclusion 1. In the patients suffering chronic hepatitis B or with posi- tive serologic HBV, male patients has greater risk to develop into intrahepatic cholangiocarcinoma. 2. Metastasis of ICC associated with primary tumor location and differentiation. 3. Blood transfusion in operation was one risk factors for tumor relapse.
出处
《肝胆外科杂志》
2012年第5期331-334,共4页
Journal of Hepatobiliary Surgery
关键词
肝内胆管细胞癌
临床特点
性别
Intrahepatic cholangiocarcinoma
Clinical features
Gender
