摘要
目的探讨连续性肾脏替代治疗(CRRT)对急性肾功能衰竭(ARF)患者血浆细胞因子的影响。方法对42例急性肾功能衰竭患者进行CRRT治疗,使用ELISA法检测治疗前和治疗后4、12、24、48 h血浆肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、IL-6、IL-8的浓度,并与同期健康人群做比较。结果 ARF患者TNF-α、IL-1β、IL-6、IL-8血浆浓度均显著高于正常对照组(P<0.01),4种细胞因子在CRRT治疗4 h开始后显著下降,12 h时浓度降至最低,24～48 h有不同程度的回升,但仍低于治疗前水平。结论 CRRT能有效清除ARF患者血浆细胞因子,从而阻断炎症反应。
Objective To investigate the effect of continuous renal replacement therapy（CRRT） on the plasma cytokines in pa- tients with acute renal failure（ARF）. Methods Forty-two patients with ARF were treated by CRRT. Levels of plasma cytokines inclu- ding tumor nectosis factor-α（TNF-α）, interleakin-1β（IL-1β）, inter leukin-6（IL-6）, inter leukin-8 （IL-8） were detected by ELISA at 0, 4, 12, 24, 48 hours after treatment. The results were compared with those of the healthy people. Results The levels of serum TNF-α, IL-1β, IL-6, IL-8 in patients with ARF were markedly higher than those of the healthy controls （ P 〈 0.01）. The cytokines started to reduce at 4 hours after CRRT and decreased to lowest levels at 12 hours after CRRT （P 〈 0. 01 ）, then slightly elevated at 24- 48 hours after CRRT, but still lower than the levels before CRRT. Conclusion CRRT can effectively clear the inflammatory cyto- kines, therefore block the inflmnmatory reactions.
出处
《临床医学》
CAS
2012年第11期34-35,共2页
Clinical Medicine
