期刊文献+

组织工程微构建与Bottom-up构建思路的研究进展

Progress in Microconstructed Technology and Bottom-up Approach for Tissue Engineering
在线阅读 下载PDF
导出
摘要 天然组织结构是由高度复杂化的组织微结构体组成,现今组织工程学的巨大挑战就是在体外重现这些微结构体的结构和功能。微构建技术为组织构建提供了一条新途径。对微工程化水凝胶技术作了相关的介绍,举例阐述了其中的微流体技术和微孔技术在形成细胞集落、促进细胞-细胞与细胞-细胞外基质间作用等方面的影响。此外,还提出了一种通过自下而上的构建方式制备水凝胶微结构的新技术,利用微囊化细胞与生物凝胶材料进行体外组织工程构建。 Naturai tissues are made from highly complex tissue microarehitectures. A maior challenge in tissue engineering is to recreate tissue construct with appropriate microarchitectures and function. The microconstructed technology provided a new approach for tissue engineering. The microengineered hydrogels technology is discussed, especially the microfluidic technology and microwell arrays technology which would promote the formation of cell colony and the interaction of cell-cell and cell extracellular matrix. In addition, a new technique to develop the complex of microencapsulated ceils and hydrogel microstructure for tissue engineering through bottom-up way is suggested.
出处 《材料导报》 EI CAS CSCD 北大核心 2012年第21期124-127,共4页 Materials Reports
基金 国家高技术研究发展计划(2006AA02A118) 国家自然科学基金(31000441 31170939) 中央高校基本科研业务费(JB-JC1009 JB-SJ1009) 东南大学生物电子学国家重点实验室开放研究基金(2011E10) 福建省自然科学基金(2011J01223)
关键词 组织工程 载细胞微凝胶 自下而上途径 微囊化细胞 tissue engineering, cell-laden microgels, bottom-up approach, microencapsulated cells
  • 相关文献

参考文献48

  • 1Ohashi K, Yokoyama T, Yamato M, et al. Engineering functional two- and three-dimensional liver systems in vivo using hepatic tissue sheets[J]. Nat Med,2007,13(7):880.
  • 2Khademhosseini A, Vacanti J P, Langer R. Progress in tissue engineering [J]. Sci Am, 2009,300(5) : 64.
  • 3Curcio E, Salerno S, Barbieri G, et al. Mass transfer and metabolic reactions in hepatocyte spheroids cultured in rotating wall gas-permeable membrane system [J]. Biomate rials, 2007,28 (36): 5487.
  • 4McClelland R E, MacDonald J M, Coger R N. Modeling 02 transport within engineered hepatic devices [J]. Biotechn Bioeng, 2003,82 (1) : 12.
  • 5Aubin H, Nichol J W, Hutson C B, et al. Directed 3D cell alignment and elongation in microengineered hydrogels [J]. Biomaterials, 2010,31 (27) : 6941.
  • 6Khademhosseini A, Langer R. Microengineered hydrogels for tissue engineering [J]. Biomaterials, 2007,28(34) : 5087.
  • 7Shah D N, Recktenwall-Work S M, Anseth K S. The effect of bioactive hydrogels on the secretion of extracellular matrix molecules by valvular interstitial cells [J]. Biomaterials, 2008,29 (13) : 2060.
  • 8Du Y, Lo E, Ali S, et al. Directed assembly of cell-laden microgels for fabrication of 3D tissue constructs[J]. Proc Natl Acad Sci USA, 2008,105 (28) : 9522.
  • 9Burdick J A, Frankel D, Dernell W S, et al. An initial investigation of photocurable threedimensional lactic acid based scaffolds in a critical-sized cranial defect [J]. Biomate rials, 2003,24 (9): 1613.
  • 10Bryant S J, Anseth K S. Controlling the spatial distributionof ECM components in degradable PEG hydrogels for tissue engineering cartilage [J]. J Biomed Mater Res A, 2003,64 (1) : 70.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部