摘要
目的观察愈伤Ⅰ号小鼠灌胃的安全性,为临床安全用药提供依据。方法用愈伤Ⅰ号或饮用水,以最大给药浓度及可承受的最大体积对小鼠一次性灌胃,3天后对比存活情况;并采用一日最大给药量灌胃,7天后对比愈伤Ⅰ号与饮用水灌胃后,小鼠体重和食量、外表行动、反应活动、饮水量及大小便情况。将小鼠最大灌胃量通过公式转换为成人每日用量。结果愈伤Ⅰ号超声雾化剂灌胃的小鼠全部存活,具有安全性;上述观察指标两组对比,差异不明显(P>0.05);小鼠一日最大给药量为3.36g,经换算相当于成人临床日用量的133倍。结论愈伤Ⅰ号超声雾化剂使用比较安全,可用于临床研究及治疗。
Objective To observe the callus-I intragastric administration security and provide the basis for clinical medication safety. Methods Mice were treated with callus-I intragastric or water with the largest tolerant volumn by in- tragastric administration. The survival rate was observed 3 days after treatment. The body weight, appetite, behavior, activity, appetite and stools were observed 7 days after treatment. Results The mice with gavage of Callus- I ultrasonic atomizing agent had survived. The indexes of the two group were not significantly different （P〉0. 05）. Conclusion Cal- lus- l ultrasonic atomizing agent is relatively safe and can be used for clinical research and treatment.
出处
《西部医学》
2012年第11期2062-2063,2066,共3页
Medical Journal of West China
基金
泸州市科学技术研究项目(编号:2004-60)
关键词
愈伤Ⅰ号
超声雾化
急性毒性实验
Callus - I
Ultrasonic atomizing
Acute toxicity test
