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急性冠脉综合征患者血清基质金属蛋白酶2的变化及其与冠状动脉病变程度的关系

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摘要 目的探讨急性冠脉综合征患者血清基质金属蛋白酶2(MMP-2)的升高水平的变化及其与冠状动脉病变程度的关系。方法应用十二烷基硫酸钠.聚丙烯酰胺凝胶电泳检测急性冠脉综合征患者血清MMP.2的水平。冠状动脉病变程度采用Gensini评分系统。结果急性心肌梗死组、不稳定型心绞痛组患者血清MMP-2水平分别为(12.168±5.887)%,(11.316±8.579)%,均高于健康对照组的(1.462±1.316)%(t=5.077、7.937,均P〈0.05)。单支病变组、双支病变组及三支病变组患者血清MMP-2水平分别为(13.693±9,715)%,(8.7224-5.941)%,(12.227±5.901)%,组间差异均统计学意义(t=5.606、5.306、7.942,均P〉0.05)。急性冠脉综合征患者血清MMP-2与Gensini积分无明显相关性(r=0.0019,P〉0.05)。结论血清MMP-2可作为评价斑块稳定性的血清学指标,亦是斑块破裂引起ACS发生的重要原因。
作者 叶建华 崔燕
出处 《中国基层医药》 CAS 2012年第23期3571-3572,共2页 Chinese Journal of Primary Medicine and Pharmacy
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