摘要
目的提高对大颗粒淋巴细胞白血病(LGLL)的认识。方法对1例T细胞大颗粒淋巴细胞白血病患者的临床资料进行分析,并复习国内外相关文献。结果 T细胞大颗粒淋巴细胞白血病患者常表现为反复感染、脾大、中性粒细胞减少或缺乏和大颗粒淋巴细胞(LGL)增多;外周血、骨髓涂片LGL增多;免疫表型通常为CD3+、CD4-、CD8+、CD16+、CD56-、CD57+、HLA-DR+;克隆性TR基因重排;常见染色体异常;排除其他LGLL。结论 T细胞大颗粒淋巴细胞白血病是慢性淋巴细胞白血病中一种少见的较独特类型,必须认真检查,才能避免漏诊误诊,免疫分型检查具有重要价值。
Objective To improve the recognition for large granular lymphocytic leukemia（LGLL）. Methods To Analyze The clinical datum of one patient with T - cell large granular lymphocytic leukemia （ T - LGLL） was analyzed and reviewed the relevant literature. Results The T - LGLL patients usually manifested as recurrent infections, splenomegaly, neutropenia or lack, and large granular lymphocytic （LGL） increased; LGL increased in peripheral blood, bone marrow smears; Phenotype was usually CD3＋ , CD4- , CD8＋ , CD16＋ , CD56- , CD57＋ , HLA-DR＋ ; Clonal TR gene rearrangement; Common chromosomal abnormalities ; Exclude other LGLL. Conclusion T - LGLL is a rare, unique type of chronic lymphocytic leukemia, must check carefully to avoid its diagnosis, the immunophenotyping check has important value.
出处
《临床医学》
CAS
2012年第10期31-32,共2页
Clinical Medicine
关键词
大颗粒淋巴细胞
白血病
外周血
骨髓
T细胞
Large granular lymphocytic
Leukemia
Peripheral blood
Bone marrow
T cell
