摘要
目的探讨降钙素原(PCT)、超敏C-反应蛋白(hs-CRP)水平、白细胞计数(WBC)在新生儿败血症早期诊断中的应用价值。方法采用电化学发光法测定血清中PCT水平,采用免疫比浊法测定血清中hs-CRP水平及两者的动态变化,用Sysmex-1800i检测WBC。结果新生儿败血症重症组血清PCT和hs-CRP水平在治疗前明显升高,与轻度组比较差异有统计学意义(P<0.05),轻度组与对照组比较差异亦有统计学意义(P<0.05)。经抗菌药物有效治疗后,PCT和hs-CRP水平与治疗前比较差异有统计学意义(P<0.05)。WBC计数在新生儿败血症组和对照组中比较差异无统计学意义。结论血清PCT和hs-CRP联合检测在新生儿败血症的早期诊断中有一定价值,动态检测PCT和hs-CRP水平有助于评估治疗效果,协助临床判断病情的转归。
Objective To investigate the application value of serum procalcition（ PCT）, hs-CRP and WBC in the early diag- nosis of neonatal sepsis. Methods PCT was determined by ECLIA and hs-CRP was determined by nephelometry, WBC was de- termined by Sysmex-1800i. Results The levels of PCT and hs-CRP in group of serious degree increased significantly, there was statistical significance compared with group of light degree （ P 〈 0.05 ）, and there was significanct difference between group of light degree and control group （ P 〈 0.05 ）. There were significanct differences in PCT and bs-CRP levels between before and af- ter the antibiotic treatment. There was no significant differenice in the WBC count between group of neonatal sepsis and coutrol group. Conclusion The combined detection of serum PCT and hs-CRP has value in the early diagnosis of neonatal sepsis. Mo- nitoring dynamically the levels of PCT and hs-CRP can help to evaluate the curative effect.
出处
《临床医学》
CAS
2012年第10期27-28,共2页
Clinical Medicine
