摘要
许多心血管疾病如原发性高血压的发生和发展,均与血管内皮细胞结构的损伤和功能异常有密切关系。而血管内皮细胞的损伤,一方面可以导致一氧化氮(nitric oxide,NO)合成减少及分泌异常,另一方面也使细胞膜对钙离子处理异常。NO和Ca2+可通过各自和两者之间的相互作用对原发性高血压的发生和发展起到重要的调控作用。
The development of many cardiovascular diseases,such as essential hypertension（EH）,is closely related to the structure damage and dysfunction of the vascular endothelial cells.The dysfunction of endothelial cell,on the one hand,can decrease the production and secretion of NO.On the other hand,Ca2＋ might be wrongly handled by membrane.Both NO and Ca2＋ play an important role in the development of hypertension through itself alone or the interaction between them.
出处
《国际病理科学与临床杂志》
CAS
2012年第5期410-415,共6页
Journal of International Pathology and Clinical Medicine
基金
国家自然科学基金(31160239)~~
