摘要
目的:探讨结直肠癌根治术中化疗综合应用的临床疗效。方法:回顾性分析我院2006年6月至2012年6月70例结直肠癌根治术患者的临床资料,其中一组采用结直肠癌根治+术中化疗(包括肠腔+腹腔+门静脉化疗)患者40例(简称试验组),并与另一组采用单纯结直肠癌根治术患者30例(简称对照组)进行比较。结果:试验组和对照组在骨髓抑制、肝肾功能损伤、术后并发症发生率比较差异无显著性(P>0.05);但术后5年生存率在Dukes A、B期的生存曲线,差异有显著性(P<0.05),在Dukes C期生存曲线,差异无显著性(P>0.05)。结论:结直肠癌根治+术中化疗不会增加对肝肾功能的损伤、骨髓造血功能抑制、术后并发症,且能提高Dukes A、B期5年生存率,是一种有效的治疗方法,值得推广应用。
] Objective To investigate the clinical efficacy of intraoperative chemotherapy in radical surgery for colorectal cancer. Methods Retrospective analysis on clinical data from 70 cases with colorectal cancer receiving radical mastectomy in our hospital from June 2006 to June 2012, among them, 40 patients received colorectal radical mastectomy combined with intraoperative chemotherapy, which referred to as the experimental group and 30 patients received colorectal radical mastectomy alone, which referred to as the control group. Results No significant differences were observed in liver and kidney dysfunction, hematopoiesis suppression, postoperative complication rate between the experimental group and the control group （P 〉 0.05）; However, the 5-year survival rate in Dukes A, B stage in the experimental group was significantly higher than that in the control group （P 〈 0.05）. However, in Dukes C stage survival curve, the difference was not significant （P 〉 0.05）. Conclusions Radical mastectomy comjbine with intraoperative chemotherapy can improve 5-year survival rate of patients at Dukes A, B stage without increasing the dysfunction of liver and kidney, suppression of hematopoiesis and postoperative complication, which indicating that radical mastectomy combine with intraoperative chemotherapy is an effective treatment strategy for patients with colorectal cancer.
出处
《实用医学杂志》
CAS
北大核心
2012年第21期3542-3544,共3页
The Journal of Practical Medicine
基金
广州市卫生局医药卫生科技项目(编号:2012A052110008)
关键词
结直肠肿瘤
术中化疗
临床疗效
Colorectal neoplasms
Intraoperative chemotherapy
Clinical efficacy
