摘要
目的观察丹红颗粒对血瘀模型大鼠血液流变学的影响，进一步探讨其活血化瘀的作用机理。方法选取SD大鼠60只，按随机数字法分正常对照组、模型对照组[予等容量0．5％羧甲基纤维素钠（CMC-Na）]，丹红颗粒高剂量组（3g／kg）、丹红颗粒中剂量组（1．5眺g）、丹红颗粒低剂量组（0．75创晦）、复方丹参滴丸组（3e,／kg）。各组均按1ml／kg容积灌胃，1次／d，连续7d。于末次给药后，采用皮下注射大剂量肾上腺素加冰水冷浴法复制大鼠血瘀证模型，观察丹红颗粒对血瘀模型大鼠血液流变学的影响。结果丹红颗粒高剂量组、复方丹参滴丸均可明显降低血瘀模型大鼠全血黏度值（高切、中切和低切值[丹红颗粒高剂量组分别为（5．69±0．16）mPa·s、（6．97±0．48）mPa·s、（22．56±1．69）mPa·S；复方丹参滴丸组分别为（5．71±0．24）mPa·S、（7．04±0．51）mPa·s、（22．63±1．64）mPa·s]；血浆黏度值丹红颗粒高剂量组为（1．43±0．03）mPa·s，复方丹参滴丸组为（1．42±0．03）mPa·s；RBC压积值丹红颗粒高剂量组为（0．42±0．027）L几，复方丹参滴丸组为（0．41±0．032）L，L。丹红颗粒中剂量组可降低血瘀模型大鼠全血黏度高切（5．95±0．37）mPa·s、低切（23．45±1．57）mPa·S，降低血浆黏度值（1．47±0．02）mPa·s；RBC压积（0．48±0．029）L几；丹红颗粒低剂量组对血瘀模型大鼠全血黏度高切（7．15±0．41）mPa·s、中切（7．86±0．36）mPa·s、低切（28．68±1．69）mPa·s、血浆黏度（1．67±0．03）mPa·s、RBC压积（0．50±0．033）几降低不明显。结论丹红颗粒高、中剂量组可降低血瘀模型大鼠的全血黏度（高切、中切和低切）、血浆黏度和RBC压积。
Objective To study the effects of Danhong Granule on blood rheology of blood stasis rats, and further to investigate the mechanism of promoting blood circulation and removing blood stasis. Methods 60 SD rats were selected and randomly divided into 6 groups, namely, normal control group, model group to the capacity of 0.5% sodium carboxymethyl cellulose （CMC-Na）, Danhong granules in high dose group （3 g/kg）, Danhong granules dose group（1.5 g/kg）, Danhong granulos low dosc group（0.75 g/kg）, and compound Danshcn dripping pill group（3 g/kg）. Each group received gastric lavage at 1 ml/kg volume, l/d, for 7 days. After the last administration, the rat model of blood stasis was reproduced by subcutaneous injection of high dose epinephrine with ice water bath method. The effects of Danhong granules on blood rheology of blood stasis model rats were studied. Results Danhong granules in high dose group and compound Danshen dripping pills could reduce blood stasis model rats in blood viscosity （high shear, cut and low cut values were： Danhong granules in high dose group were（5.69±0.16）mPa＇s, （6.97±0.48）mPa＇s, （22.56±1.69） mPa＇s; Compound Danshen Dropping PiU group （5.71 ± 0.24） mPa-s, （7.04 ± 0.51） mPa-s, （22.63 ±1.64） mPa.s, plasma viscosity respectively： Danhong granules in high dose group were （1.43 ±0.03）mPa.s, compound Danshen dripping pill group（1.42±0.03）mPa＇s, RBC （hematocrit value were： Danhong granules in high dose group were （0.42± 0.027） L/L, compound Danshen dripping pill group （0.41 ± 0.032） L/L; Danhong granules dose group could significantly lower the blood stasis model rats in blood viscosity （high, low cut）value （5.95 ± 0.37） mPa.s,（23.45 ± 1.57） mPa-s, plasma viscosity（1.47 ± 0.02）mPa-s and RBC hematocrit value （0.48 ± 0.029） L/L low dose group; Danhong granules low dose group could reduced blood stasis model rats obviously in blood viscosity （high shear, cut and low shear）, plasma viscosity and hematocrit values of RBC [respectively ： the whole blood viscosity in （7.15 ± 0.41） mPa ± s, （7.86±0.36）mPa ± s, （28.68±l.69）mPa ± s, （1.67±0.03）mPa ± s, （0.50± 0.033）L/L] . Conelusion Danhong Granule can reduce the blood stasis model rats in blood viscosity （high shear, cut and low shear）, plasma viscosity and hematocrit value of RBC, by activating blood circulation, removing blood stasis and improving blood rheology.
出处
《国际中医中药杂志》
2012年第11期997-999,共3页
International Journal of Traditional Chinese Medicine
