摘要
A simple precipitation method was proposed to prepare naproxen micro-particles with different controllable morphologies, using capillary video microscopy to study the precipitation process. Different particle shapes were obtained including spherical, platelet-like, stick-like, needle-like, and butterfly-like, all in the micro-size range. It was found that the sizes and morphologies of the formed naproxen particles were sensitive to the nature and concentration of the added surfactant, and depended significantly on processing conditions such as temperature, stirring speed, and initial drug concentration. In addition, pre- cipitation with different surfactant types and concentrations would not affect the crystal microstructure of the formed nanroxen oarticles.
A simple precipitation method was proposed to prepare naproxen micro-particles with different controllable morphologies, using capillary video microscopy to study the precipitation process. Different particle shapes were obtained including spherical, platelet-like, stick-like, needle-like, and butterfly-like, all in the micro-size range. It was found that the sizes and morphologies of the formed naproxen particles were sensitive to the nature and concentration of the added surfactant, and depended significantly on processing conditions such as temperature, stirring speed, and initial drug concentration. In addition, pre- cipitation with different surfactant types and concentrations would not affect the crystal microstructure of the formed nanroxen oarticles.
基金
support provided by National Natural Science Foundation of China(Nos.21121064 and 20990224)
National Science and Technology Ministry(No.2008BAE64B02)
