摘要
目的探究分析以雷贝拉唑钠、克拉霉素、阿莫西林为主的三联疗法在临床上对胃溃疡的治疗效果。方法回顾性分析本院2011年5～10月收治的112例胃溃疡患者的临床资料,将其随机分为对照组(56例)和观察组(56例);对照组给予阿莫西林、奥美拉唑联合治疗,观察组则接受雷贝拉唑钠、克拉霉素联合阿莫西林的治疗方法,通过观察患者溃疡愈合情况、不良反应和幽门螺杆菌(Hp)根除率来比较两组方法的治疗效果。结果观察组患者接受治疗后,其溃疡总愈合率为94.6%,显著高于对照组,差异有统计学意义(P<0.05);观察组不良反应的概率明显低于对照组,差异有统计学意义(P<0.05);观察组Hp根除率较高于对照组,但差异无统计学意义(P>0.05)。结论雷贝拉唑三联方案具有疗程短、安全性高、Hp根除率较高、不良反应少、愈合率高等优点,值得在临床上广泛应用。
Objective To research and analysis the effects of rabeprazole,dmoxicinin and claritnromycin-based triple therapy for treatment of gastric ulcer.Methods The clinical data of 112 cases of gastric ulcer from May to October 2011 were retrospectively analyzed and they were randomly and equally divided into treatment group（56 cases） and control group（56 cases）.The control group were recepted dmoxicinin＋ rabeprszole therapy,and the treatment group were given rabeprszole＋ cluritnromycin＋ dmoxicinin triple therapy regimen;By compared the two groups＇ ulcer healing rates,adverse reactions and the rate of Hp eradication to evaluate the effect of the two different therapies.Results Gastric ulcer cure rate of observation group was 94.6%,it was significantly higher than that of control group,and the difference was statistically significant（P 0.05）;and the adverse reactions of observation group was obviously lower than control group,and the difference was statistically significant（P 0.05）;the rate of Hp eradication was higer than that of control group,but the difference was not statistically significant（P 0.05）.Conclusion The rabeprazole-based triple therapy with short course,high security,higher rate of Hp eradication,fewer adverse reactions,high ulcer healing rate,and it is worthy of clinical application.
出处
《中国当代医药》
2012年第29期78-79,共2页
China Modern Medicine
