摘要
目的探讨番茄红素对人体的安全性和抗氧化作用。方法将120名健康志愿者按血清丙二醛(MDA)含量随机分为试食组和对照组,试食组连续服用番茄红素90 d,对照组服用安慰剂,测定2组人群血清中MDA含量及超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)活性和安全性指标。结果试食前后,试食组志愿者血清MDA含量分别为4.06和3.61 nmoL/mL,下降11.03%;SOD活性分别为90.7和96.7 U/mL,上升6.80%;GSH-Px活性分别为122.6和136.9 NU/mL,上升11.74%,与对照组比较,差异均有统计学意义(P<0.01);试食前后2组人群各项安全性指标均在正常范围内。结论番茄红素可提高人体抗氧化能力,且对人体健康无损害。
Objective To assess antioxidant effects of lycopene and its impact on human health.Methods A tatal of 120 healthy volunteers were divided into test group and control group randomly according to serum content of malondialdehyde（MDA）.Subjects in test group were orally given lycopene consecutively for 90 days.Contents of MDA,activities of superoxide dismutase（SOD） and glutathione peroxidase（GSH-Px）,and indexes of safety were determined at 90th day of the trial.Results In the test group,MDA content was 4.06 nmoL/mL before feeding and 3.61 nmoL/mL after feeding,with a decrease rate of 11.03%.The SOD activity was 90.7 U/mL before feeding and 96.7 U/mL after feeding,with an increase rate of 6.80%.The GSH-Px activity was 122.6 NU/mL before feeding and 136.9 NU/mL after feeding,with an increase rate of 11.74%.The indexes of test group were all significantly different from those of the control group（P0.01 for all）.All safety indexes were in normal range.Conclusion Lycopene could enhance antioxidative function and has no toxic effect observed in human body.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2012年第11期1475-1476,共2页
Chinese Journal of Public Health
