摘要
苯并咪唑类分子是含有苯环和咪唑环的杂环芳香族有机化合物,具有抗肿瘤、抗菌等多种生物活性,在药学和医学等领域有广泛的使用。同时由于其特殊的环结构和电子效应,该类衍生物是一类重要的有机合成中间体,也可用作过渡金属的配体,金属表面处理剂等。本文综述了苯并咪唑衍生物的合成方法,对国内外最新的合成工作进行讨论,为今后的研究提供帮助。
Benzimidazole is a heterocyclic aromatic organic compound,which consists of the fusion of benzene and imidazole. The benzimidazole ring plays a substaintial roal in modern drug progress for its unique pharmaeophore. Benzimidazole derivatives as anti-microbial and antitumor have been proved highly effectual medicament. As an important organic intermediate, benzimidazoles were used as transition metal ligands,metal surface treatment agents. Research of benzimidazoles was presented in the paper,which provided a theoretical basis for the further valuable research.
出处
《浙江化工》
CAS
2012年第10期21-24,共4页
Zhejiang Chemical Industry
关键词
苯并咪唑
邻苯二胺
有机合成
benzimidazole
o-phenylenediamine
organic synthesis
