摘要
目的:检测妊娠期糖尿病(gestational diabetes mellitus,GDM)患者的糖化血红蛋白(glycosylated hemoglobin A,HbA1C)水平,分析HbA1C在GDM血糖监测及预测新生儿不良结局中的意义。方法:根据HbA1C水平将149例GDM患者分为低HbA1C(LH)组(HbA1C≤5.6%)和高HbA1C(HH)组(HbA1C>5.6%)。分别检测两组的血压、血糖、血脂,记录分娩后新生儿的情况,比较两组各指标的差异并进行HbA1C与各指标的相关性分析。结果:HH组的体重(W)、体重指数(BMI)、空腹血糖(FBG)、HbA1C明显高于低LH组(P<0.05);HbA1C与BMI、W、新生儿体重、FBG呈正相关(r分别为0.840、0.804、0.357、0.241,P<0.05);HH组新生儿发生低血糖、巨大儿的情况较LH组明显增加,比值比分别为3.63、4.84。结论:HbA1C在GDM患者血糖监测及预测新生儿低血糖和巨大儿的发生中有重要作用。
Objective： To detect the levels of glycosylated hemoglobin （HbAlc） in patients with gestational diabetes mellitus （GDM） , and analyze the significance of HbAlc for blood glucose monitoring of patients with GDM and predicting adverse outcome of neonates. Methods： According to the levels of HbA1 C, 149 GDM patients were divided into low HbA1C （LH） group （HbA1C ≤5.6% ） and high HbA1C （HH） group （HbA1C 〉5.6% ） . The blood pressures, blood glucose levels, and blood lipids in the two groups were detected; neonatal situations in the two groups after birth were recorded; the indexes in the two groups were compared, and a correlation analysis between HbA1 C and each index was conducted. Results： Body weight, body mass index （BMI）, fasting blood glucose, and HbA1 C level in HH group were statistically significantly lower than those in LH group （ P 〈 0. 05 ） ; there was a positive correlation between HbA1C and BMI, body weight, neonatal weight, and fasting blood glucose, respectively （ γ= 0. 840, 0. 804, 0. 357, O. 241, P 〈 0.05 ） ; the incidences of hypoglycemia and macrosomia in HH group Were statistically significantly higher than those in LH group, the odds ratio were 3.63 and 4. 84, respectively. Conclusion： HbA1C plays an important role in blood glucose monitoring of GDM patients and predicting the occurrences of neonatal hypoglycemia and macrosomia.
出处
《中国妇幼保健》
CAS
北大核心
2012年第31期4864-4866,共3页
Maternal and Child Health Care of China
基金
秦皇岛市科学技术研究与发展计划第二批项目〔201101A325〕
关键词
妊娠期糖尿病
糖化血红蛋白
巨大儿
低血糖
Gestational diabetes mellitus
Glycosylated hemoglobin
Macrosomia
Hypoglycemia
