摘要
目的比较全身磁共振弥散加权成像(WB-DWI)和生长抑素受体显像(SRS)在发现及定位瘤源性骨质软化症患者致病瘤灶的准确性。方法 6例临床疑诊瘤源性骨质软化症的患者,均于2周内分别行WB-DWI及SRS检查,评价两种检查方法发现致病瘤灶的价值,并以手术切除的病理诊断作为金标准,比较两者的敏感性、特异性及准确性。结果手术病理证实的致病瘤灶包括软组织肿瘤2例(血管脂肪瘤及间叶组织肿瘤各1例)及骨肿瘤1例(恶性神经纤维瘤)。WB-DWI和SRS发现瘤源性骨质软化症患者致病瘤灶的敏感性、特异性及准确性分别为:WB-DWI:33.33%、100%、66.67%;SRS:33.33%、66.67%、50%。两种方法比较差异无统计学意义(P>0.05)。结论对于成年的骨质软化症患者,应选择WB-DWI及SRS检查以寻找致病瘤灶,两者相互补充,为临床提供更加全面的信息。
Objective To compare the accuracy of whole body diffusion weighted magnetic resonance imaging （WB-DWI） with that of somatostatin receptor scintigraphy （SRS） in the detection and localization of the lesions in patients with oncogenic osteomalacia （OOM）. Methods Totally 6 patients with clinically sus- pected oncogenic osteomalacia were enrolled. All of them underwent WB-DWI and SRS within 2 weeks to eval- uate the possible presence of tumors that lead to osteomalacia. Surgical and pathological findings were consid- ered as the gold standard. The sensitivity, specificity, and accuracy were calculated.~ Results Pathology con- firmed the diagnosis of two soft tissue tumors （ including 1 angiolipoma and 1 mensenchumal tumor） and one bone tumor of malignant neurofibroma. The sensitivity, specificity, and accuracy in the identification of lesions in patients with oncogenic osteomalacia were 33.33%, 100%, 66.67% for WB-DWI and 33.33%,66.67%, 50% forSRS （P〉0.05）. Conclusion For can provide mutually supportive data and be used for iden adult patients with osteomalacia, WB-DWI and SRS tifying potential oncogenic osteomalacia.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2012年第5期437-442,共6页
Acta Academiae Medicinae Sinicae
关键词
磁共振弥散加权成像
全身成像
生长抑素受体显像
骨质软化症
diffusion weighted magnetic resonance imaging
whole body imaging
somatostatin receptor scintigraphy
osteomalacia
