摘要
目的探讨MR DWI在Graves病病情评估中的价值。方法对82例经临床确诊的活动期Graves病患者及15名健康受试者行DWI,b值取0和1000s/mm2,分别测量甲状腺两侧叶中部水平的ADC值;比较不同病情活动期Graves病甲状腺实质的ADC值的差异;对ADC值与甲状腺功能指标(FT3、FT4、TSH和24h摄碘率)进行相关性检验。结果不同病情活动期Graves病的ADC值差异有统计学意义(F=16.57,P<0.01),两两比较差异亦有统计学意义(P均<0.05);Graves病甲状腺实质ADC值与血清FT3(r=0.40,P<0.01)、FT4(r=0.31,P<0.01)均呈正相关,与TSH及24h吸碘率无相关性(P>0.05)。结论 DWI在Graves病病情评估中具有一定指导作用。
Objective To investigate the value of MR diffusion weighted imaging （DWI） in evaluating the severity of ac tive Graves disease. Methods DWI with b value 0 and 1000 s/ram2 was performed in 82 patients with clinically diagnosed active Graves disease and 15 healthy volunteers. Apparent diffusion coefficient （ADC） values of bilateral lobes at middle portions were measured. The differences were analyzed between different groups. Correlation analysis was performed a mong ADC values and thyroid functional laboratory test serum free triiodothyronine （FT3）, free thyroxine （FT4）, thyroid stimulating hormone （TSH） and 24 hours＂ thyroid radioiodide uptake （RAIU）. Results There was statistical difference a- mong different severities （F= 16.57, P〈0.01）, multiple comparisons between any two groups also displayed statistical differences （all P〈0. 05）. ADC values had positive correlation with serum FT3 （r= 0. 40, P〈0.01）, FT4 （r= 0.31, P〈0. 01）, but had no correlation with TSH and 24 hours＂ thyroid RAIU （P〈O. 05）. Conclusion DWI is helpful to evaluating the severity of active Graves disease.
出处
《中国医学影像技术》
CSCD
北大核心
2012年第11期1977-1981,共5页
Chinese Journal of Medical Imaging Technology
关键词
扩散磁共振成像
表观扩散系数
甲状腺疾病
Diffusion magnetic resonance imaging
Apparent diffusion coefficient
Thyroid disease
