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溶酶体蛋白酶cathepsin L在阿尔茨海默病模型大鼠海马组织中的表达及意义 被引量：1

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摘要 目的观察阿尔茨海默病(AD)大鼠海马组织中溶酶体蛋白酶cathepsin L的表达。方法采用Aβ-淀粉样肽(Aβ)大鼠海马注射制作AD动物模型。用免疫荧光染色和Western印迹法检测大鼠海马组织cathepsin L的表达。结果 Aβ海马内灌注造成Aβ沉积的AD模型在行为学和病理改变上一定程度地模拟了AD。AD大鼠海马区cathepsin L蛋白表达与正常组大鼠相比显著升高,cathepsin L蛋白荧光检测发现AD大鼠海马区cathepsin L阳性神经元数量明显增加。结论在AD大鼠海马组织中cathepsin L表达升高。
作者 郭燕君
机构地区 嘉兴学院医学院
出处 《中国老年学杂志》 CAS CSCD 北大核心 2012年第21期4703-4705,共3页 Chinese Journal of Gerontology
基金 嘉兴市科技局课题(No.2009AY2068)
关键词 阿尔茨海默病 溶酶体蛋白酶cathepsin L Β-淀粉样肽
分类号 R322.81 [医药卫生—人体解剖和组织胚胎学]
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参考文献6

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  • 3Hook VY.Unique neuronal functions of cathepsin L and cathepsin B in secretory vesicles:biosynthesis of peptides in neurotransmission and neu-rodegenerative disease(J).Biol Chem,2006;387(10-11):1429-39.
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同被引文献9

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中国老年学杂志
2012年 第21期

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