摘要
背景:对肿瘤干细胞表面标志物进行检测及跟踪监测研究,可为肿瘤的诊断及生物治疗如免疫治疗等提供重要的帮助。目的:对肺癌的肿瘤干细胞表面标志物的研究进行文献检索分析,为提高肿瘤的诊断率、改善治疗方法、提高患者的生活质量提供可借鉴的理论依据。方法:检索SCI数据库2002/2011肺癌肿瘤干细胞表面标志物研究相关文献,采用检索词为"肿瘤干细胞(cancer stem cell);肺癌(lung cancer)",共检索110篇文献,选取符合标准的18篇文献进行数据分析。结果与结论:肺癌是目前世界上发病率和死亡率最高的恶性肿瘤之一,检测肺癌肿瘤干细胞表面标志物CD133可深入研究肿瘤发生、发展及增殖、维持过程,同时CD133可以为肺癌的靶向生物治疗提供相关信息。随着研究的不断深入,肿瘤干细胞表面标志物不仅可以应用于肿瘤的早期诊断,还将应用于肿瘤的生物治疗。
BACKGROUND：Detecting,tracking and monitoring the surface markers of cancer stem cells can provide important help for tumor diagnosis and biological treatments,such as immunotherapy.OBJECTIVE：To review the articles on the surface markers of cancer stem cells in order to provide the reference theoretical basis for tumor diagnosis and improving the treatment methods and life quality.METHODS：The SCI database was searched for the articles on the surface markers of cancer stem cells published from 2002 to 2011.The key words were ＂cancer stem cell,lung cancer＂ in English and Chinese.A total of 110 articles were screened out and finally 18 articles were included to review according to the inclusion criteria.RESULTS AND CONCLUSION：Lung cancer is one of the malignant tumors with highest morbidity and mortality in the world.Detection of lung cancer stem cell surface marker,CD133,can help to study the occurrence,development and proliferation and maintaining process of tumors,and CD133 can provide relevant information for targeted biological treatments of lung cancer.With the deepening of the study,the cancer stem cell surface markers cannot only be applied for the early diagnosis of the tumor,but also be applied for the biological treatment of the tumor.
出处
《中国组织工程研究》
CAS
CSCD
2012年第36期6827-6833,共7页
Chinese Journal of Tissue Engineering Research
