摘要
为探讨茶色素对高胆固醇兔动脉粥样硬化的影响 ,将 2 4只新西兰雄性白兔按血脂水平随机分为对照组、茶色素低剂量组 [32 μg (g·d) ]和高剂量组 [96 μg (g·d) ],每组 8只 ,实验期间均以高胆固醇饮食。喂养 8周后处死动物 ,测定血脂水平、血浆内皮素水平和斑块面积比。结果发现 ,实验 4周及 8周后血清总胆固醇和甘油三酯水平明显高于实验前 ,但三组间没有明显差异。实验 8周后对照组、茶色素低剂量组和高剂量组血浆内皮素水平分别为 775 .5 8± 6 6 8.72 μg L、2 5 1.73± 2 41.5 7μg L和 6 5 .43± 17.18μg L。与对照组相比 ,茶色素低剂量组内皮素水平有所降低 ,但无显著性差异 (P >0 .0 5 ) ,茶色素高剂量组内皮素水平明显降低 (P <0 .0 5 )。对照组、茶色素低剂量组和高剂量组动物胸主动脉斑块面积百分比分别为 0 .793± 0 .0 77、0 .5 88± 0 .2 0 5和 0 .437± 0 .116 ,内膜面积与中膜面积百分比分别为 0 .6 2 5± 0 .2 0 6、0 .32 6± 0 .2 76和 0 .175± 0 .0 92 ,茶色素组斑块面积明显低于对照组 (P <0 .0 5 )。结果提示 ,茶色素能够防止兔实验性粥样斑块的形成 。
Aim To investigate the effects of tea pigment on experimental atherosclerosis in hypercholesterolemia rabbits.Methods According to serum cholesterol and triglyceride level twenty-four rabbits were divided into control group fed with high cholesterol diet, low dose tea pigments group fed with high cholesterol diet and 32 μg/g·d tea pigments orally, high dose tea pigments group fed with high cholesterol diet and 96 μg/g·d tea pigment orally. After 8 weeks, all animals were killed to determine the serum lipids, plasma endothelin, the percent of thoracic aorta inner surface covered by plaque and the ratio of intimal to medial cross-sectional areas in ascendent aorta. Results Tea pigments had no effect on lipid level within the experimental doses.The plasma endothelin level was reduced in high dose tea pigments group (P<0.05). The aorta plaque areas in both tea pigment groups were significantly lower than that of control group (P<0.05). Conclusions It is suggested that tea pigments could protect the formation of aorta plaque and reduce the level of endothelin in plasma in the hypercholesterolemia rabbits.
出处
《中国动脉硬化杂志》
CAS
CSCD
2000年第2期131-133,共3页
Chinese Journal of Arteriosclerosis
