期刊文献+

多发脑转移瘤的放疗效果及预后分析

暂未订购
导出
摘要 目的总结多发脑转移瘤患者的放疗疗效和预后因素。方法回顾性分析多发脑转移瘤82例患者的资料,全脑放射治疗+立体定向放射治疗(WBRT+SRT)37例,全脑放射治疗(WBRT)45例。SRT剂量分割模式依据转移瘤的部位、体积、病理、患者一般状况和既往治疗确定,总剂量为16~30 Gy/2~6次或10~12Gy/单次,WBRT总剂量为30~40 Gy/2~3 Gy/次,3~4周,应用Kaplan-Meier和Cox回归分析研究各因素对预后的影响。结果全组中位生存期(MST)为10个月。WBRT+SRT组、WBRT组1年总生存率分别为37.84%、28.90%(P<0.05)。单因素分析显示原发病灶控制与否、颅外病变情况、预后分级评分(GPA)分级、原发灶诊断至脑转移时间是影响生存的因素(P<0.05)。结论 SRT及WBRT是多发脑转移瘤患者有效的治疗手段,WBRT+SRT组和WBRT组的生存无差异,颅外病变进展的患者预后差。
出处 《宁夏医学杂志》 CAS 2012年第10期995-996,共2页 Ningxia Medical Journal
  • 相关文献

参考文献4

  • 1张永权,赵贤军,刘文力,康笃伦.脑转移瘤的放射外科治疗进展[J].国外医学(神经病学.神经外科学分册),2002,29(3):216-218. 被引量:10
  • 2Nussbaum ES,Djalilian HR,Cho KH,et al. Brain metastases. His-tology multiplicity surgery and survivalf J]. Cancer, 1996,78 ; 1781-1788.
  • 3姜雪松,肖建平,宋一昕,张可,翟万聪,张烨,李晔雄.大于3cm脑转移瘤分次立体定向放疗初探[J].中华放射肿瘤学杂志,2009,18(3):176-180. 被引量:12
  • 4James frazier,Sachin batra,Sumit kapor,et al. Stereotactic radiosur-gery in the management of brain metastases: an institutional retro-spective analysis of survival [ J]. Int J Radiation Oncology BiolPhys,2010,76(5) :1486 -1492.

二级参考文献23

  • 1AndrewsDW ScottCB SperdutoPW FlandersAE GasparLE SchellMC Werner-WasikM DemasW RyuJ BaharyJP SouhamiL RotmanM MehtaMP CurranWJJr.Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase Ⅲ resuIts of the RTOG 9508 randomised trial[J].中国神经肿瘤杂志,2004,2(3):192-192. 被引量:225
  • 2刘原照,李高峰,刘明远,肖素华,褚德发.老年人脑转移瘤X线立体定向放射治疗疗效分析[J].中华老年医学杂志,2005,24(1):24-26. 被引量:2
  • 3Noel G, Proudhom MA, Valery CA, et al. Radiosurgery for reirradiation of brain metastasis: results in 54 patients. Radiother Oncol, 2001, 60(1): 61-67.
  • 4Shaw E, Scott C, Souhami L, et al. Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG protocol 90-05. Int J Radiat Oncol Biol Phys, 2000, 47 (2): 291-298.
  • 5Feuvret L, Germain I, Comu P, et al. Importance of radiotherapy in stereotactic conditions (radiosurgery) in brain metastasis: experience and results of the Hospital Pitie- Salpetriere Group. Cancer Radiother, 1998; 2 (3): 272-281.
  • 6Goodman KA, Sneed PK, McDermott MW, et al. Relationship between pattern of enhancement and local control of brain metastases after radiosurgery. Int J Radiat Oncol Biol Phys, 2001, 50(1): 139-146
  • 7Uchino M, Nagao T, Seiki Y, et al. Radiosurgery for cystic metastatic brain tumor. No Shinkei Geka, 2000, 28 (5): 417-421.
  • 8Karlsson B, Ericson K, Kihlstrom L, et al. Tumor seeding following stereotactic biopsy of brain metastases. Report of two cases. J Neurosurg, 1997, 87(2): 327-330.
  • 9Maesawa S, Kendziolka D, Thompson TP, et al. Brain metastases in patients with no known primary tumor, Cancer, 2000, 89(5): 1095-1101.
  • 10Shu HKG, Sneed PK, Shiau CY, et al. Factors Influencing Survival After Gamma Knife Radiosurgery for Patients with Single and Multiple Brain Metastases. Cancer J Sci Am, 1996, 2(6): 335 - 359.

共引文献20

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部