摘要
目的：探讨周围型肺癌ＣＴ强化与微血管密度（ＭＶＤ）的关系，以提高对肺结节的鉴别诊断能力。材料和方法：对４０例周围型肺癌（鳞癌 １８例，腺癌 ２２例）应用非离子型造影剂进行动态 ＣＴ扫描（剂量 １．５ｍｌ／ ｋｇ体重，流速３ｍｌ／ｓ，分别在注射后０．５，１，２，３，４ｍｉｎ扫描）并测量ＣＴ值，肺癌标本进行微血管密度测定，并比较肺癌增强模式和最大增强幅度与微血管密度的关系。结果：４０例肺癌平均强化值为 ５０．６５± １９．５９Ｈｕ，峰值在注射造影剂后１ｍｉｎ。腺癌与鳞癌的增强幅度无显著性差异（分别为５３．４５±２３．２２Ｈｕ及４７．２２±１４．６３Ｈｕ，Ｐ＞０．０５），而腺癌的ＭＶＤ明显低于鳞癌（分别为４５．１１±１１．２５和６１．４４±９．９１，Ｐ＜０．０５）。肺癌ＣＴ强化值与微血管密度呈正相关（ｒ＝０．８８７４，Ｐ＜０．００１）。结论：肺癌ＣＴ增强的幅度及模式与其血供及微血管密度有关，动态增强可以反映肺癌的强化特征，有助于诊断。
Purpose: To explore the correlation of CT enhancement and microvessel densities(MVDs) in peripheral lung cancer ,in order to improve the capacities for differential diagnosis of the pulmonary nodules. Materials and Methods: Spiral dynamic enhancement scanning(pre - contrast and 0. 5, 1, 2, 3, 4minutes post - contrast) in 40 patients with peripheral lung cancer(18 squamous cell carcinoma and 22 adenocarcinoma) was performed, and the CT attenuations were measured. The resected tumor specimens were immunohistochemically stained with factor for measuring MVDs. Then the MVDs were compared with the enhancement patterns and peak values. Results: The mean enhancement value in 40 patients was 50. 65 ± 19. 59Hu, and the peak value appeared at 1 minute after administration of contrast agent. The mean enhancement value of adenocarcinomas was not significantly different from that of squamous cell carcinomas(53. 45 ± 23. 22Hu, 47. 22 ± 14. 63Hu respectively ， P > 0. 05). The MVD of adenocarcinoma was lower than that of squamous cell carcinoma(61. 44 ± 9. 91 ± 45. 11 ± 11. 25 respetively, P < 0. 05). It was evident that the enhancement correlated well positively with MVD of the lung cancer(r = 0. 8874, P < 0. 001). Conclusion: The degrees and patterns of enhancement correlated closely with the blood supply and MVDs of lung carcinoma. Spiral dynamic CT scan can demonstrate the enhancement characteristics of lung carcinoma and might be helpful in diagnosis.
出处
《中国医学计算机成像杂志》
CSCD
2000年第3期172-175,共4页
Chinese Computed Medical Imaging
关键词
肺癌
CT
动态增强
微血管密度
Lung cancer CT Dynamic enhancement Microvessel density
