摘要
目的:探讨过敏性紫癜患儿外周血核细胞CD40/CD40L的表达与预后的相关性。方法:45例初发过敏性紫癜患儿(观察组)积极采用综合治疗,同期选择正常健康儿童45例(对照组),采集外周抗凝血进行核细胞CD40/CD40L的表达检测。结果:45例患儿显效42例,无效3例,无死亡患儿,有效率为93.3%。两组CD40mRNA的表达水平差异无统计学意义,观察治疗前后对比也无明显差异(P>0.05)观察组中CD40LmRNA表达高于正常对照组(P<O.05),加入PHA后CD40L mRNA表达均明显增高(P<O.05);加入Dex后,观察组CD40L mRNA表达明显减少(P<0.05)。治疗后两组对比都无明显差异(P>0.05)。结论:过敏性紫癜患儿外周血核细胞CD40/CD40L的高表达可扩大B细胞活化的规模,从而导致大量抗体的生成而参与发病,与预后呈负相关。
Objective To investigate the relation of peripheral blood nuclear cells CD40/CD40L expression and prognosis in allergic purpura children. Methods 45 children with allergic purpura （the observation group） were actively given the integrated treatment, and selected 45 normal healthy children （the control group）, All children were collected peripheral anti-clotting blood for the nuclear cells CD40/CD40L expression detecting. Results There were 42 cases were cured, the effective rate of 93.3%. The CD40mRNA expression levels of the two groups had no significant difference before and after treatment （P〉 0.05）,The CD40LmRNA expression of the observation group were higher than the control group （P〈0.05）, and were increased significantly after added PHA （P〈0.05）, and the CD40L mRNA expression was significantly decreased after added Dex in the observation group（P〈0.05）, but had little changed in the control group （P〉0.05）. Conclusion The high expression of blood nuclear cells CD40/CD40L can expand the size of B cell activation in the allergic purpura children that results in the generation of a large number of antibodies involved in the pathogenesis was negatively correlated with the prognosis.
出处
《中国美容医学》
CAS
2012年第09X期142-143,共2页
Chinese Journal of Aesthetic Medicine
