摘要
目的 :研究乳腺癌雌孕激素水平、雌孕激素受体及c erbB 2癌基因蛋白的表达情况及其临床意义。方法 :分别应用12 5I放射免疫组化ABC法研究了 82例乳腺癌和 6 8例乳腺良性病变患者血清雌孕激素水平以及病变组织雌孕激素受体、癌基因c erbB 2的表达。结果 :乳腺癌组的雌激素水平和癌基因c erbB 2的表达率明显高于良性病变组 ,雌激素水平与腋淋巴结状况呈明显正相关。ER、PR的表达与腋淋巴结状况关系不大 ,但与临床分期呈明显负相关 ,ER的阳性表达者 5年无瘤生存率明显高于复发或死亡者。癌基因c erbB 2的阳性表达率与临床分期及远期生存率呈显著正相关。结论 :雌孕激素水平高、癌基因c erbB 2的阳性表达是乳腺癌预后不良的指标 ,ER、PR的阳性表达是乳腺癌预后良好的指标 ,对乳腺癌的诊断治疗和预后判断具有重要的指导意义。
Objective:To reveal the hormone level and the expression of ER,PR and c erbB 2 gene protein in breast cancer and their clinical significance Methods:We had detected hormone levels and expression of ER,PR and c erbB 2 in 82 cases of breast cancer and 68 cases of benign breast disease,using radioimmunologic method for assaying the hormone levels and using immunohistochemistric techniques (ABC method) for detecting the expression of ER,PR and c erbB 2 Results:The estrogen level in breast cancer was siginficantly higher tnan in benign disease.We found the significant relationship between estrogen level and lymph node status.ER and PR negatively correlated with clinical TNM stages,but c erbB 2 positively correlated with them.In postoperative five years cancer free cases of breast cancer the estrogen level was lower than recuring or death cases.Conclusions:For breast cancer,the high hormone levels and positive expression of c erbB 2 might serve as indicators for poor prognosis,but ER and PR positive expression were indicators for well prognosis.
出处
《肿瘤防治杂志》
2000年第2期135-137,共3页
China Journal of Cancer Prevention and Treatment
关键词
乳腺癌
甾体激素
ER
PR
C-ERBB-2
breast cancer
estrogen and progesterone
ER
PR
c erbB 2 gene protein
