摘要
目的 :探讨p16和p2 7在乳腺癌的表达特点及其判断乳腺癌患者预后的意义。方法 :应用免疫组化ABC法检测 89例乳腺癌的p16、p2 7的表达情况。结果 :89例乳腺癌中 ,p16蛋白阳性表达率4 8 3% (4 3/ 89) ,p2 7蛋白阳性表达率 57.3% (51/ 89)。p16蛋白在腋淋巴结转移阳性组表达率 31.8%(14/ 4 4 ) ,显著低于腋淋巴结转移阴性组表达率 6 4 .4 % (2 9/ 4 5) (P <0 .0 1)。p2 7蛋白在浸润性乳腺癌组和腋淋巴结转移阳性组表达率分别为 52 .0 % (39/ 75)、38.6 (17/ 4 4 ) ,显著低于非浸润性乳癌腺组和腋淋巴结转移阴性组的表达率 85.7% (12 / 14)、75.6 % (34/ 4 5) (P <0 .0 5、P <0 .0 1)。结论 :p16蛋白与p2 7蛋白的缺失表达均与乳腺癌的生物学行为有关。p2 7蛋白检测在判断乳腺癌患者预后方面比p16蛋白检测可能有更重要意义。
Objective:To study the expression of p16 and p27 in breast cancer and its significance in pathogenesis, infiltration and lymphnode matastasis.Methods:89 cases of breast cancer were detected by ABC immunohistochemical technique.Results:The positive rates of two expression products were as follows:48.3%(p16)and 57.3%(p27).p16 protein expression was correlated with lymphnode metastasis;p27 protein expression was correlated with both pathological staging and lymphnode metastasis.Conclusions:Both p16 and p27 negative expression is significantly related to the biological behavior of breast cancer.p27 protein may be more important than p16 protein in predict the prognosis of breast cancer.
出处
《肿瘤防治杂志》
2000年第2期132-134,共3页
China Journal of Cancer Prevention and Treatment
关键词
乳腺癌
P16蛋白
P27蛋白
免疫组化
预后
protein p16
protein p27
breast cancer
immunohistochemistry
biological behavior
prognosis
