摘要
目的 :探讨阴性精神分裂症认知功能的改善与 HVA和 5-HIAA变化的关系。 方法 :对 13例阴性精神分裂症在氯氮平治疗前和治疗 8周后分别采用韦氏成人记忆量表 ( WMS) ,数字划消测验和威斯康星卡片分类测验 ( Wisconsin card sorting test,WCST)评估其记忆、注意及执行功能 ,采用高效液相色谱 -电化学检测测定其治疗前和治疗后脑脊液中 DA代谢产物高香草酸 ( HVA)和 5-HT代谢产物五羟吲哚乙酸 ( 5-HIAA)的浓度。 结果 :部分短时记忆随 HVA降低或 5-HIAA的增高而改善。而总的记忆商数 ( MQ) ,注意及执行功能的改善与 HVA和 5-HIAA的变化无明显相关。 结论 :大部分阴性精神分裂症认知功能的改善与 DA和
Objective:To explore the relationship of negative schizophrenic cognitive function improvement with HVA and 5 HIAA. Method:Thirteen negative schizophrenic patients were treated with clozapine for 8 weeks.Memory,attention,executive function were assessed separately with Waise memory scale (WMS),cancellation test (CT) and Wisconsin card sorting test (WCST) before and after treatment,and cerebrospinal fluid (CSF) HVA and 5 HIAA levels were determined with HPLC ECD. Results:Part of short memory was improving with decreasing of HVA or increasing of 5 HIAA,while significant correlation were not found between improvement of memory quotient (MQ),attention,executive function and change of HVA,5 HIAA. Conclusion:The great part of negative schizophrenic cognitive function improvement has marked correlation with change of DA and 5 HT.
出处
《临床精神医学杂志》
2000年第3期157-159,共3页
Journal of Clinical Psychiatry
