摘要
目的探讨Fisher综合征(MFS)的临床特点和发病机制,加深对本病的认识。方法回顾性分析9例MFS(其中复发型MFS 1例)患者的临床资料,分析其临床特点。结果 9例均有共济失调、眼肌麻痹、腱反射减弱或消失的三联征表现;病理反射均为阴性;6例患者存在四肢乏力。辅助检查:4例发病2～4周脑脊液出现蛋白—细胞分离现象;8例行肌电图检查均提示神经源性损害;头颅MRI或CT检查均正常。丙种球蛋白治疗后病情均有所缓解。结论 MFS为自限性疾病,预后较好;复发型病例罕见;丙种球蛋白治疗MFS有效。
Objective To investigate the clinical features and pathogenesis of Miller Fisher syndrome （MFS）, and deepen understanding of the disease . Methods The clinical data of nine MFS cases were analyzed retrospectively.Results The neurological symptoms and signs of all patients were diplopia , ophthalmoplegia and tendon areflexia （9 ca- ses）, negative pathological reflexes （9 cases）, and limb weakness （6 cases）. Supplementary examination： increased protein （4 patients） was detected in the cerebrospinal fluid, but the number of cells was normal in 2-4 weeks;eight patients were found neural injury in electromyography （EMG） ;no positive finding in computer tomography （CT） or magnetic resonance imaging （MRI） were found. Patients had a good response to intravenous immunoglobulins. Conclusions MFS is a self- limiting disease, and the prognosis was good;the recurrent pattern can be considered a rare type;intravenous immunoglobu- fins treatment is effective.
出处
《山东医药》
CAS
2012年第39期29-31,共3页
Shandong Medical Journal
