摘要
以乙脒盐酸盐、丙二酸二乙酯为原料 ,经环合、硝化、氯代反应制得合成莫索尼定的中间体4,6 -二氯 -5 -硝基-2 -甲基嘧啶 ,并对反应所用试剂及后处理过程进行了改进 ,提高了产品收率 ,总收率达70.6 %
Dichloro-5-nitro-2-methylpyrimidine,a intermediate of Moxonidine,was prepared from acetamidine hydrochloride and diethyl malonate by cyclization,chlorization and nitration.The reagents used in reaction and aftertreatment processes was improved.Total yield reaches 70.6%.
出处
《河北化工》
2000年第2期34-34,共1页
Hebei Chemical Industry
关键词
二氯
硝基
甲基嘧啶
抗高血压药
中间体
dichloro-5-nitro-2-methylpyrimidine
cyclization
chlorization
nitration
