摘要
目的:研究聚甲酚磺醛溶液的局部刺激性,以期为临床合理用药提供依据。方法:本实验通过肉眼及病理组织学观察,研究给药期及恢复期聚甲酚磺醛溶液多次给药对完整和家兔破损阴道黏膜及皮肤的刺激性。结果:聚甲酚磺醛溶液对家兔完整及破损阴道黏膜有轻度刺激反应,但无病理性损害;对完整皮肤无刺激反应,对破损皮肤有轻度刺激反应。结论:聚甲酚磺醛溶液具有选择性的凝固作用,对坏死或病变组织可致蛋白质坏死变性脱落,对物理屏障完整的组织则无明显刺激作用;其对屏障损坏后的皮下组织的轻度刺激属药物效应的固有体现,而非不良反应。
Objective： In order to provide a basis for clinical medication ofpolicresulen solution, the local stimulation was evaluated. Methods： Four experiments with multiple dosing were carried out on rabbit＇s intact and damaged vaginal mucosa and skin and the stimulation was observed by naked eyes and histopathology method during the delivery and recovery periods. Results： Policresulen solution has mild stimulation on rabbit＇s intact and damaged vaginal mucosa, but no pathological damage. It has mild stimulation on damaged skin, but not on intact skin. Conclusion： Policresulen solution has selective solidification, which results in denaturation and falling off of proteins in necrosis or diseased tissues, and has no significant stimulation on the tissues under an intact physical barrier. Mild irritation ofpolicresulen solution on the subcutaneous tissues with destructive barrier is an inherent manifestation of drug effect, rather than adverse reactions.
出处
《上海医药》
CAS
2012年第21期23-25,28,共4页
Shanghai Medical & Pharmaceutical Journal
关键词
聚甲酚磺醛溶液
阴道黏膜
皮肤刺激
policresulen solution
vaginal mucosa
skin stimulation
