摘要
目的探讨噻托溴铵吸入对改善COPD患者急性加重和气流受限的作用。方法选择2009年1月～2011年4月在我院进行治疗的慢性阻塞性肺疾病(COPD)患者40例为研究对象,采取随机双盲的原则随机分为研究组和对照组。研究组吸入噻托溴铵治疗,对照组吸入安慰剂。随访1年,比较两组患者急性加重情况及肺功能改善情况。结果研究组急性加重的比例及每人每年平均加重次数少于对照组(P<0.05或P<0.01),研究组治疗前后各肺功能指标均有显著改善(P<0.05或P<0.01),均优于对照组(P<0.05)。结论噻托溴铵吸入用于COPD稳定期治疗可以减少急性加重的发生,改善气流受限。
Objective To discuss the clinical effect of Tiotropium bromide on exacerbation and airflow in patients with COPD. Methods Selected 40 cases with chronic obstructive pulmonary disease from Jan 2009 to Apr 2011 were divided into study group and control group randomly. Study group was treated with iotropium bromide. Control group inhaled placebo. Following up for 1 year, the exacerbation and improving of pulmonary function of two groups were compared. Results Exacerbation ratio and frequency per person per year on average of study group were lower than control group（P 〈 0.05 or P 〈 0.01）. Index of pulmonary function in study group after treatment were better than before treatment（P 〈 0.05 or P 〈 0.01）, and which in study group were better than control group after treatment （P 〈 0.05）,and was better than control group （P 〈0.05）. Conclusion Tiotropium bromide inhaled in treatment of chronic obstructive pulmonary disease can de- crease exacerbation and improve airflow limitation.
出处
《中国现代医生》
2012年第31期57-58,61,共3页
China Modern Doctor
