摘要
目的观察大剂量阿托伐他汀强化治疗对NSTE-AMI患者心功能的影响。方法 74例NSTE-AMI患者随机分为阿托伐他汀常规治疗组(20 mg/晚)及强化治疗组(40 mg/晚),超声测量治疗24 h内及3个月后左室射血分数(LVEF)及左室舒张末内径(LVEDd),并于24 h内、3个月测定血浆NT-proBNP。结果两组患者LVEF、LVEDd及NT-proBNP在治疗3个月后与治疗24 h内比较差异有统计学意义(P<0.05),强化治疗组LVEF较常规治疗组升高更明显,LVEDd则进一步下降,血浆NT-proBNP亦进一步下降。结论大剂量阿托伐他汀较常规剂量治疗NSTE-AMI心力衰竭可以进一步提高心功能,改善预后。
Objective To explore the effect of high dose of atorvastatin on changes of left ventricular function in patients with acute non ST elevation myocardial infarction （NSTE-AMI） randomly. Methods Seventy-four cases of NSTE-AMI pa- tients were devided into conventional treatment group （atorvastatin 20 mg/d） and intensive treatment group （atorvastatin 40 rag/d）, left ventricular ejection fraction （LVEF） and left ventricular end diastolic diameter（LVEDd） were measured by ul trasound after 24 hours and 3 months treated, and plasma level of NT-pro brain natriuretic peptide （NT-proBNP） were measured at the same time. Results There were significant differences in the levels of LVEDd,LVEF and NT-proBNP be tween the conventional treatment group and the intensive treatment group after 3 month treatment （P 〈 0.05）. LVEF in the intensive treatment group was higher than in the conventional treatment group but LVEDd was the reversed,plasma NT- proBNP decreased in the intensive treatment group more significantly than in the other （P 〈 0.05）. Conclusion High dose of atorvastatin can improve heart function and improve the long-term prognosis in NSTE-AMI patients.
出处
《中国现代医生》
2012年第29期76-78,共3页
China Modern Doctor
关键词
阿托伐他汀
非ST段抬高型心梗
心功能
Atorvastatin
Non-ST elevation acute myocardial infarction
Heart function
