摘要
目的探讨氨基末端脑利钠肽前体(NT-proBNP)在老年(>60岁)心功能不全住院患者中的诊断意义及预后价值。方法选取95例心衰患者设为观察组,24例心功能正常者设为对照组,测定入院时血浆中的NT-proBNP水平,评价NYHA心功能分级,研究NT-proBNP水平与NYHA心功能分级的关系,同时通过6个月～1年的随访,了解有无不良事件发生。结果①观察组的NYHAⅡ、Ⅲ、Ⅳ级与对照组的血浆NT-proBNP水平两两比较差异有统计学意义(P<0.05),心功能越差,血浆NT-proBNP水平越高;②血浆NT-proBNP水平与心功能等级呈正相关(r=0.715,P<0.05);③统计住院119例住院患者出院后半年到1年内发生的不良事件(猝死,中风,因心衰再次住院),发生不良事件的患者其NT-proBNP表达水平比未发生不良事件患者的水平高,两者比较差异有统计学意义(P<0.05)。结论入院时NT-proBNP表达水平是诊断老年住院患者心功能不全的可靠指标,与老年住院患者心衰的严重程度密切相关,入院时NT-proBNP水平可在一定程度上判断老年心衰患者的预后。
Objective To explore the diagnostic significance and prognostic value of NT-proBNP for the hospitalized el- derly patients （〉60 years） with heart failure. Methods A total of 95 cases with heart failure patients were selected as ob- servation group, 24 persons with normal heart function were selected as control group, determined the plasma NT-ProBNP during hospitalization, evaluated the NYHA cardiac function classification, researched the correlation between NT-proBNP level and NYHA cardiac function classification. At the same time, with the follow-up for 6 months to one year, the adverse events were observed. Results （1）There was the statistical difference （P 〈 0.01） when comparing the NYHA !1, llI, 1V in observation group with plasma NT-proBNP level in control group and when comparing the NT-proBNP expression level of those patients occurring the adverse events with those not occurring. The worse the heart function, the higher the plasma NT-proBNP level; （2）The positive correlation between plasma NT-proBNP level and heart function was observed（r = 0.715, P 〈 0.01）. Conclusion NT-proBNP expression level is a reliable indicator for the diagnosis of elderly heart failure, which is closely related with the severity of elderly heart failure. NT-proBNP expression level during hospitalization can judge the prognosis of elderly heart failure to some degree.
出处
《中国现代医生》
2012年第29期62-64,共3页
China Modern Doctor
