摘要
目的:本文旨在探讨近年来肝郁证相关动物实验研究的造模对象、手段各方面的多样性和规范性。方法:分别在近年相关学术著作和杂志文献方面进行小结,针对造模干预方法、实验动物选择、造模干预后检验等方面进行比较和总结。结果:通过研究,从造模干预方法可将文献归为6类:不可预知慢性刺激方法;夹尾打斗法;夹尾法;束缚法;肝气逆、肝气郁理论法;引用国外文献一类。并发现大鼠为主要实验动物,束缚法为主要造模手段。结论:最终认为造模干预手段多样且具有较强客观性,近年标准化进展的加快将为肝郁造模技术提供良好提升空间。
Objective： The article discusses the multiplicity and specification of the liver depression model’s methods.Methods： It summarized the information in the monograph and treatise public at recent years,and focus on the some aspects such as model methods,the selection of the experimental animal and the test about the model we made.Results： We find six mainly methods： unpredictability chronic stress methods;fighting while catching tail method;tail catch method;constraint method and liver qi theory and foreign method.We find that rat is the most popular animal that used in the experiment and the constraint method is most widely used among six methods.Conclusion： The research expresses the multiplicity and objectivity in the liverdepression syndrome model’s establishment and the development of the standardization can promote the maturity of the technique of the liver-depression syndrome model.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2012年第11期2842-2847,共6页
China Journal of Traditional Chinese Medicine and Pharmacy
关键词
肝郁
造模
多样性
Liver depression
Model’s establishment
Multiplicity
