摘要
为提高术前化疗的疗效,我们探索动静脉结合的化疗方法。静脉缓慢输注时间依赖性药物以维持其作用时间,动脉局部注射浓度依赖性药物以提高其局部浓度,以不同的给药途径充分发挥两类药物的药理作用。2002年以动静脉结合的FLEP疗法(静脉缓慢注射5-FU与亚叶酸钙,动脉局部注射足叶乙甙与顺铂)应用于临床,取得了满意的初步效果。其后以毒性较低的奥沙利铂代替顺铂,使化疗的毒性明显降低。随后又在动脉给药中加入表阿霉素,使动脉给药形成了类似于EAP方案的EEOX给药方案,形成动静脉结合的FLEEOX(静脉缓慢注射5-FU与亚叶酸钙,动脉局部注射足叶乙甙、表阿霉素与奥沙利铂)方案。临床实践表明该方案的局部作用非常剧烈,使化疗有效率超过80%,对局部进展期胃癌的疗效明显优于传统途径的化疗。
Objective： A combination of intravenous and intra-arterial intensified chemotherapy was explored to improve preoperative chemotherapeutic efficacy. Cell cycle （phase）-specific drugs were administrated by slow intravenous infusion to prolong drug ac- tion time, whereas drugs that were not cell cycle-specific were administered via the celiac artery to improve local drug concentration. The FLEP regimen （i.e., intravenous 5-Fu and leucovorin, as well as intra-arterial etoposide and cisplatin） has been shown to be promising since its use for preoperative treatment of advanced gastric cancer in 2002. Cisplatin was replaced by oxaliplatin to reduce toxicity, and epirubicin was added to the local intra-arterial infusion such as the EAP regimen （i.e., etoposide, doxorubicin, and cisplatin） in more recent clinical practice. The FLEEOX regimen （i.e., 5-Fu, leucovorin, oxaliplatin, epirubicin, and etoposide） was then adminis- tered. With its powerful local therapeutic efficacy, this regimen has exhibited significant advantage in treating locally advanced gastric cancer over some conventional chemotherapeutic regimens, with more than 80% response rate.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2012年第20期1481-1484,共4页
Chinese Journal of Clinical Oncology
基金
南京军区重点课题(编号:08228)资助
关键词
术前化疗
动静脉结合给药
进展期胃癌
Gastric cancer
Pre-operative chemotherapy
Combination of intravenous and intraarterial intensified chemotherapy
