摘要
[目的]探讨灌肠液合中药煎剂内服治疗慢性肾功能衰竭(chronic renal failure,CRF)的临床疗效。[方法]研究分组:对32名2008年1月至2012年1月在我院接受治疗的未接受肾脏替代CRF患者按年龄大小、病程长短、慢性肾脏疾病(chronic kidney disease,CKD)分期从轻至重顺序及性别均衡选择原则随机分成对照组和治疗组,两组各16例。对照组采用(1)先行原发病治疗。对患者的血压、心功能、血容量、电解质、酸碱平衡等定期诊查并及时纠治;重视患者的感染源及疲劳度等逆转增恶因素的考虑。(2)饮食营养配合。在内生肌酐清除率(creatinine clearance rate,Ccr)<40mL.min-1时,随Ccr调整蛋白质摄入量;重视患者热量的供给和磷摄入量的控制。治疗组在对照组治疗基础上加(1)中药灌肠治疗,间日1次,每日腹泻超过4次者暂停1d,4周为1个疗程并观察疗效。(2)中药煎剂、随症加减内服,l剂/d,上下午分服,连服4周为1疗程并观察疗效。[结果]治疗组总有效率为87.50%,对照组总有效率为43.75%,两组疗效比较差异有统计学意义(P<0.05),提示灌肠液合中药煎剂内服治疗组疗效优于常规治疗对照组。[结论]灌肠液合中药煎剂内服治疗CRF,能有效地改善病人的症状和肾功能,疗效确切且有价廉、安全、无毒副作用等优点。
[Objective] To explore the clinical effect of clysis fluid and TCM decoction on CRF.[Method] Groups： Divide the 32 patients into treatment and control groups under age,course,chronic kidney disease（CKD） stages,both n=16.Treatment：（1） ①the control group is centered on primary disease,periodically diagnose and treat their pressure,heart function,blood volume,electrolyte and acid-base balance;pay attention to their infection and labor,and other bad factors.②Diet nutrition,at Creatinine clearance rate（Ccr）40mL·min-1,regulate protein intake with Ccr;pay attention to patients＇ caloric and P intake.（2）For treatment group,① added with TCM enema,4w as a course,then observe the effect.② Take revised TCM decoction orally,also 4w as a course.[Result] The total effective rate was 87.50% for treatment group,and 43.75% for control one,there＇s difference of statistical meaning,showing the method above is better than routine treatment.[Conclusion] Clysis fluid and TCM decoction treating CRF can effectively relieve patients＇ symptoms and improve renal function,with definite cure effect,with good points of being cheap,safe,without side effects.
出处
《浙江中医药大学学报》
CAS
2012年第10期1089-1091,共3页
Journal of Zhejiang Chinese Medical University
