摘要
目的验证口服地屈孕酮的孕激素活性,了解超排周期黄体支持后子宫内膜的变化。方法将2010年6～9月本中心47例超排卵后有卵巢过度刺激综合征倾向患者按不同黄体支持方法随即分为两组:A组(22例)采用肌内注射黄体酮针进行黄体支持:B组(25例)采用口服地屈孕酮进行黄体支持。7天后进行诊刮,取子宫内膜活检,测定hCG注射日雌二醇(E2)水平,并测量诊刮日子宫内膜厚度。结果子宫内膜活检提示注射黄体酮针组,18例(81.82%)转化为分泌期,3例(13.64%)为分泌期伴分泌不足,1例(4.55%)仍为增生期;口服地屈孕酮组,17例(68%)转化为分泌期,5例(20%)为分泌期伴分泌不足,3例(12%)仍为增生期。两组患者黄体支持后的子宫内膜较hCG日有增厚的趋势,但无统计学意义(P>0.05)。结论口服地屈孕酮用于体外受精治疗中的黄体支持效果与黄体酮针剂相似,且依从性更优。
Objective To validate the biological activity of dydrogesterone and study the changes of endometrium in the subsequent controlled ovarian hyper - stimulation（COH） cycle of luteal support. Methods Forty seven cases after COH due to ovarian hyperstimnla- tion syndrome（OHSS） from June 2010 to September 2010 were divided into 2 groups： group A （simple intramuscular progesterone） with 22 cases and group B （ simple dydrogesterone） witn 25 cases according to different ways of luteal support. All patients were followed up for endometrium pathological examination after 7 days. At the same time, endometrium thickness was observed. Blood test for measuring the level of E2 was performed on the day of hCG injection. Results Eighteen cases（81.82% ） were of secretory phase,3 cases（ 13.64% ）of deficient secretory phase, 1 case （4.55 % ） of proliferation phase after intramuscular progesterone. Seventeen cases （68 % ） were of secretory phase,5 cases（20% ） of deficient secretory phase,3 cases （ 12% ） of proliferation phase after dydrogesterone followed with phathological diagnosis. The endometrium thicknesses after luteal support was thicker than that at the hCG＇s day,but the difference had no statistical sig- nificance （P 〉 O. 05）. There was also no significant difference between the two groups in the level of E2. Conclusion Oral dydrogester- one has not only the same effect compared to intramuscular progesterone in leteal - phase supplementation but also the good compliance.
出处
《医学研究杂志》
2012年第10期109-112,共4页
Journal of Medical Research
关键词
黄体支持
地屈孕酮
子宫内膜
分泌期
Luteal support
Dydrogesterone
Endometrium
Secretory phase
