摘要
概述了头孢唑啉的主要合成路线。第一条路线,7-ACA(7-氨基头孢烷酸)和噻二唑、四氮唑乙酸反应;第二条路线,GCLE先和噻二唑反应,然后脱去3位和7位的保护基团,最后和四氮唑乙酸缩合;第三条路线,噻二唑和四氮唑乙酸先形成活性硫醇酯,再与7-ACA反应;第四条路线,以噻唑淋—吖丁啶酮为起始原料进行反应。
This article summarizes main methods of synthesising cefazolin. There are four synthesising routes. First route, a beginning material is 7-ACA. 7-ACA reacts with 2-mercapto-5-methylthiadiazole and tetrazole-1-acetic acid. Now it is main method of productive cefazolin. Second route, a beginning material is GCLE. GCLE reacts with 2-mercapto-5-methylthiadiazole. The reactant take off protective groups which lie in 3-place and 7-place. Then the compound reacts with tetrazole-1-acetic acid. This route is newer and good. Third route, 2-mercapto-5-methylthiadiazole and tetrazole-1-acetic acid form active thiol ester. Then the ester reacts with 7-ACA. This method isn't used in produce,bnt it has high yield and less procedure. There is a good prospect. Fourth route,a beginning material is thiazoline-azetidinones. It is in a study stage.
出处
《山西化工》
2000年第2期14-15,共2页
Shanxi Chemical Industry
