摘要
目的 :探索小儿术后镇痛硬膜外持续输注吗啡最佳有效剂量。方法 :32例择期手术患儿随机分为三组 ,各组吗啡负荷量、维持量分别为 :组Ⅰ 10 μg/kg、1μg·kg-1·h-1;组Ⅱ 2 0 μg/kg、2 μg·kg-1·h-1;组Ⅲ 30 μg/kg、3μg·kg-1·h-1。术后定时进行镇痛、镇静评分及不良反应的观察。结果 :镇痛评分组Ⅱ、Ⅲ明显低于组Ⅰ (P <0 0 5 ) ,镇静评分组Ⅰ、Ⅱ明显低于组Ⅲ (P <0 0 5 ) ,不良反应发生率三组间无显著性差异。结论 :吗啡负荷量 2 0 μg/kg、维持量 2
Objective: Searching for the appropriate dose regimen of morphine for pediatric postoperative analgesia via continuous epidural infusion.Methods:32 patients undergoing elective surgery were randomly assigned to three groups.A loading dose of 3～5ml morphine was given via epidural cathater at the end of surgery,then a continuous dose of morphine in 2ml/h was given in the ward and maintained for 48h.In group Ⅰ, loading dose was 10μg/kg,maintaining dose 1μg·kg -1 ·h -1 ;In group Ⅱ and group Ⅲ,20μg/kg and 2μg·kg -1 ·h -1 ,30μg/kg and 3μg·kg -1 ·h -1 respectively.The assessment of postoperative pain, sedation and adverse reactions was conducted at regular intervals.Results:Pain scores in group Ⅱ and Ⅲ were significantly lower than that in group Ⅰ ( P< 0 05);sedation scores in group Ⅰ and Ⅱ were significantly lower than that in group Ⅲ ( P< 0 05);the incidence of adverse reactions had no significant difference among three groups.Conclusions:Loading dose 20μg/kg,maintaining dose 2μg·kg -1 ·h -1 of morphine might be the appropriate dose regimen for pediatric postoperative analgesia via continuous epidural infusion.
出处
《临床麻醉学杂志》
CAS
CSCD
2000年第3期123-124,共2页
Journal of Clinical Anesthesiology
