摘要
目的观察参一胶囊联合吉西他滨+顺铂(GP)方案治疗晚期非小细胞肺癌的疗效和毒副作用。方法治疗组35例,对照组35例,均采用GP化疗方案,即吉西他滨(GEM)1000mg/m2静脉滴注第1,8天,顺铂(DDP)25mg/m2第1～3d,21d为1周期,每治疗2～3周期,治疗组加用参一胶囊20mg空腹口服bid,与化疗同步,21d为1疗程。结果两者疗效比较无统计学(P>0.05),治疗组血液学性毒性和消化道副反应发生率明显低于对照组,有统计学差异(P<0.05)。结论参一胶囊联合GP方案治疗晚期非小细胞肺癌可降低化疗对患者的毒副作用,改善患者生存质量。
Objective To observe the efficary and toxicity of Shenyi caps combined with GP regimen in treatment of advanced non-small-cell lung cancer.Methods Gemcitabin 1g/m 2 ivgtt D1,8 and DDP 25mg/m2 ivgtt D1-3 combined with Shenyi caps 20mg PO bid×21 were used in the treated group.The control group only received GP therapy.Results The therapeutic effectiveness were not significantly different between the treatment group and control group（P0.05）.The hematological toxicity and gastrointestinal reactions in the treated group were significantly lower than those in the control group（P0.05）.Conclusion Shenyi caps combined with GP regimen is effective intreating advanced NSCLC with lower toxicities.
出处
《当代医学》
2012年第31期1-2,共2页
Contemporary Medicine
关键词
参一胶囊
非小细胞肺癌
临床观察
Shenyi caps
Non-small-cell lung cancer
Clinical observation
