摘要
目的 :探讨Askin瘤的本质、起源。方法 :以临床病理观察、免疫组织化学、电子显微镜技术和细胞遗传技术对 2 2例Askin瘤进行研究。结果 :显示瘤细胞免疫组化为MIC2 (CD99) ,NSE、CgA阳性 ;电镜下见神经分泌颗粒 ;细胞遗传分析示特异性基因遗传异位 ,即t(11;2 2 ) (q2 4;q12 )。这些特点与恶性原始神经外胚叶肿瘤 (PNET)相同。 结论 :Askin瘤实际上是PNET/尤文肉瘤家族的一员 ,只是发生部位较特殊 ,预后不良。应与其它小圆细胞肉瘤如淋巴瘤、胚胎型横纹肌肉瘤、横纹肌样瘤、圆形细胞脂肪肉瘤。
Purpose To study the origination and reality of Askin tumor Method Twenty two cases of these lesions had been studied by clinical pathologic observation, immunohistochemistry, electron microscopy, and cytogenics Results The results revealed the positivity of MIC2(CD99), NSE, Chromogranin A(CgA) by immunohistochemistry, neurosecretory granules by electron microscopy, and the specific genotypic translocation of t(11:22)(q24:q12) by cytogenetic analysis, which were identical to the malignant primitive neuroectodermal tumor (PNET) Conclusion The results shows that this lesion is actually the one member of the PNET/Ewings sarcoma family, except the special location Differential diagnoses should be made between this tumor and other small round cell sarcoma such as lymphoma, embryonal rhabdomyosarcoma, rhabdoid tumor, round cell liposarcoma and desmoplastic small round cell tumor.
出处
《临床与实验病理学杂志》
CAS
CSCD
2000年第1期8-10,共3页
Chinese Journal of Clinical and Experimental Pathology
